L
Lois S. Weisman
Researcher at University of Michigan
Publications - 98
Citations - 8710
Lois S. Weisman is an academic researcher from University of Michigan. The author has contributed to research in topics: Vacuole & Vacuole inheritance. The author has an hindex of 48, co-authored 90 publications receiving 7843 citations. Previous affiliations of Lois S. Weisman include University of Iowa & Life Sciences Institute.
Papers
More filters
Journal ArticleDOI
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Xian-Ping Dong,Dongbiao Shen,Xiang Wang,Taylor Dawson,Xinran Li,Qi Zhang,Xiping Cheng,Yanling Zhang,Lois S. Weisman,Markus Delling,Haoxing Xu +10 more
TL;DR: It is proposed that TRPMLs regulate membrane trafficking by transducing information regarding PI(3,5)P(2) levels into changes in juxtaorganellar Ca(2+), thereby triggering membrane fusion/fission events.
Journal ArticleDOI
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
Clement Y. Chow,Yanling Zhang,James J. Dowling,Natsuko Jin,Maja Adamska,Kensuke Shiga,Kinga Szigeti,Michael E. Shy,Jun Li,Jun Li,Xuebao Zhang,James R. Lupski,Lois S. Weisman,Miriam H. Meisler +13 more
TL;DR: A multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation in the ‘pale tremor’ mouse is described and a novel form of autosomal recessive Charcot–Marie–Tooth disorder is designated CMT4J.
Journal ArticleDOI
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
TL;DR: It is proposed that Fab1p and Vac7p are components of a signal transduction pathway which functions to regulate the efflux or turnover of vacuolar membranes through the regulated production of PtdIns(3,5)P2.
Journal ArticleDOI
Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow,John Landers,John Landers,Sarah K. Bergren,Peter C. Sapp,Peter C. Sapp,Peter C. Sapp,Adrienne E. Grant,Julie M. Jones,Lesley Everett,Guy M. Lenk,Diane McKenna-Yasek,Diane McKenna-Yasek,Lois S. Weisman,Denise A. Figlewicz,Robert H. Brown,Robert H. Brown,Miriam H. Meisler +17 more
TL;DR: Heterozygosity for a deleterious allele of FIG4 appears to be a risk factor for ALS and PLS, extending the list of known ALS genes and increasing the clinical spectrum of FIG3-related diseases.
Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow,John Landers,John Landers,Sarah K. Bergren,Peter C. Sapp,Peter C. Sapp,Peter C. Sapp,Adrienne E. Grant,Julie M. Jones,Lesley Everett,Guy M. Lenk,Diane McKenna-Yasek,Diane McKenna-Yasek,Lois S. Weisman,Denise A. Figlewicz,Robert H. Brown,Robert H. Brown,Miriam H. Meisler +17 more
TL;DR: In this paper, the authors described nonsynonymous variants of FIG4 in 2% (9/473) of patients with ALS and primary lateral sclerosis (PLS) and showed that a deleterious FIG4 allele appears to be a risk factor for both diseases.