L
Long Jun Wu
Researcher at Mayo Clinic
Publications - 159
Citations - 11833
Long Jun Wu is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Microglia & Long-term potentiation. The author has an hindex of 54, co-authored 157 publications receiving 9290 citations. Previous affiliations of Long Jun Wu include Harvard University & University of Toronto.
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Journal ArticleDOI
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Muhammad M. Hossain,Blair C. Weig,Kenneth R. Reuhl,Marla Gearing,Long Jun Wu,Jason R. Richardson,Jason R. Richardson,Jason R. Richardson +7 more
TL;DR: It is suggested that zonisamide may reduce neuroinflammation through the down‐regulation of microglial Nav 1.6, which is highly expressed in microglia of post‐mortem PD brain and of mice treated with the parkinsonism‐inducing neurotoxin MPTP.
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CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain.
Chun-Lin Mai,Zhi Tan,Ya-Nan Xu,Jing-Jun Zhang,Zhen-Hua Huang,Dong Wang,Hui Zhang,Wen-Shan Gui,Jun Zhang,Zhen-Jia Lin,Ying-Tong Meng,Xiao Wei,Ying-Tao Jie,Peter M. Grace,Long Jun Wu,Li-Jun Zhou,Xian-Guo Liu +16 more
TL;DR: CXCL12-mediated monocyte recruitment into the perivascular space is critical for neuroinflammation and the resultant cognitive impairment in neuropathic pain.
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Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex.
TL;DR: It is found that the presence of NVP-AAM007 did not significantly affect the effect of ifenprodil on NMDAR-mediated EPSCs and could be used as a selective antagonist for NR2A-containing N MDARs in the ACC.
Journal ArticleDOI
Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons.
Long Jun Wu,Yong Li,Tian Le Xu +2 more
TL;DR: A novel cross‐modulation between the two inhibitory cotransmitters systems may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions.
Journal ArticleDOI
Optogenetic activation of spinal microglia triggers chronic pain in mice.
Min Hee Yi,Yong Liu,Anthony D. Umpierre,Tingjun Chen,Yanlu Ying,Jiaying Zheng,Aastha Dheer,Dale B. Bosco,Hailong Dong,Long Jun Wu +9 more
TL;DR: In this article, the authors used optogenetic approaches in microglia to address this question employing CX3CR1creER+: R26LSL-ReaChR+ transgenic mice, in which red-activated channelrhodopsin (Rea-ChR) is inducibly and specifically expressed in micro-glia.