L
Lonneke Scheffer
Researcher at University of Oslo
Publications - 18
Citations - 723
Lonneke Scheffer is an academic researcher from University of Oslo. The author has contributed to research in topics: Computer science & Biology. The author has an hindex of 6, co-authored 16 publications receiving 347 citations. Previous affiliations of Lonneke Scheffer include Norwegian Institute of Public Health & Hanze University of Applied Sciences.
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Journal ArticleDOI
Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary.
TL;DR: Scoary is introduced, an ultra-fast, easy-to-use, and widely applicable software tool that scores the components of the pan-genome for associations to observed phenotypic traits while accounting for population stratification, with minimal assumptions about evolutionary processes.
Journal ArticleDOI
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding.
Rahmad Akbar,Philippe Robert,Milena Pavlović,Jeliazko R. Jeliazkov,Igor Snapkov,Andrei Slabodkin,Cédric R. Weber,Lonneke Scheffer,Enkelejda Miho,Ingrid Hobæk Haff,Dag Haug,Fridtjof Lund-Johansen,Yana Safonova,Geir Kjetil Sandve,Victor Greiff +14 more
TL;DR: In this paper, the authors identify structural interaction motifs, which together compose a commonly shared structure-based vocabulary of paratope-epitope interactions, and show that this vocabulary enables the machine learnability of antibody-antigen binding using generative machine learning.
Posted ContentDOI
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding
Rahmad Akbar,Philippe Robert,Milena Pavlović,Jeliazko R. Jeliazkov,Igor Snapkov,Andrei Slabodkin,Cédric R. Weber,Lonneke Scheffer,Enkelejda Miho,Ingrid Hobæk Haff,Dag Haug,Fridtjof Lund-Johansen,Yana Safonova,Geir Kjetil Sandve,Victor Greiff +14 more
TL;DR: The largest available set of non-redundant antibody-antigen structures are screened for binding patterns and identified structural interaction motifs are identified, which together compose a vocabulary of paratope-epitope interactions that is universally shared among investigated antibody-antsigen structures.
Journal ArticleDOI
Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective.
Tone Kristin Bjordal Johansen,Lonneke Scheffer,Lonneke Scheffer,Lonneke Scheffer,Veronica Klausmark Jensen,Jon Bohlin,Siri Laura Feruglio +6 more
TL;DR: The results indicate that human brucellosis in Norway is related to travels or migration from the Middle East, Asia or Africa, in accordance with results from Germany, Denmark and Sweden.
Posted ContentDOI
One billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction
Philippe Robert,Rahmad Akbar,Frank R,Milena Pavlović,Michael Widrich,Igor Snapkov,Maria Chernigovskaya,Lonneke Scheffer,Andrei Slabodkin,Brij Bhushan Mehta,Vu Mh,Prósz A,Abram K,Abram K,Olar A,Enkelejda Miho,Haug Dtt,Fridtjof Lund-Johansen,Sepp Hochreiter,Ingrid Hobæk Haff,Günter Klambauer,Geir Kjetil Sandve,Greiff +22 more
TL;DR: The Absolut! as mentioned in this paper software suite enables the generation of synthetic lattice-based 3D-antibody-antigen binding structures with ground-truth access to conformational paratope, epitope, and affinity.