L
Lorenzo M. Refolo
Researcher at National Institutes of Health
Publications - 35
Citations - 3464
Lorenzo M. Refolo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genetically modified mouse & Amyloid precursor protein. The author has an hindex of 17, co-authored 34 publications receiving 3307 citations. Previous affiliations of Lorenzo M. Refolo include Nathan Kline Institute for Psychiatric Research.
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Journal ArticleDOI
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Lorenzo M. Refolo,Miguel A. Pappolla,Brian Malester,John LaFrancois,Tara Bryant-Thomas,Rong Wang,G. Stephen Tint,Kumar Sambamurti,Karen Duff +8 more
TL;DR: It is proposed that diet can be used to modulate the risk of developing AD and high dietary cholesterol increases Aβ accumulation and accelerates the AD-related pathology observed in this animal model.
Journal ArticleDOI
A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease
Lorenzo M. Refolo,Miguel A. Pappolla,John LaFrancois,Brian Malester,Stephen D. Schmidt,T. Thomas-Bryant,G. S. Tint,Rong Wang,Marc Mercken,Suzana Petanceska,Karen Duff +10 more
TL;DR: It is demonstrated that hypocholesterolemia is associated with reduced Abeta accumulation suggesting that lowering cholesterol by pharmacological means may be an effective approach for reducing the risk of developing AD.
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Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
Miguel A. Pappolla,Tara Bryant-Thomas,Donald Herbert,Javier Pacheco,M. Fabra Garcia,M. Manjon,Xavier Gironès,Tracey L. Henry,Etsuro Matsubara,Daniel Zambón,Benjamin Wolozin,Mary Sano,Félix F. Cruz-Sánchez,Leon J. Thal,Suzana Petanceska,Lorenzo M. Refolo +15 more
TL;DR: Serum hypercholesterolemia may be an early risk factor for the development of AD amyloid pathology.
Journal ArticleDOI
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
Etsuro Matsubara,Tara Bryant-Thomas,Javier Pacheco Quinto,Tracey L. Henry,Burkhard Poeggeler,Donald Herbert,Félix F. Cruz-Sánchez,Yau Jan Chyan,Mark A. Smith,George Perry,Mikio Shoji,Koji Abe,Anna Leone,Inge Grundke-Ikbal,Glen L. Wilson,Jorge Ghiso,Christina L. Williams,Lorenzo M. Refolo,Miguel A. Pappolla +18 more
TL;DR: Administration of melatonin partially inhibited the expected time‐dependent elevation of β‐amyloid, reduced abnormal nitration of proteins, and increased survival in the treated transgenic mice, and these findings may bear relevance to the pathogenesis and therapy of AD.
Journal ArticleDOI
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Karen Duff,H. Knight,Lorenzo M. Refolo,Sunny Sanders,Xin Yu,M. Picciano,Brian Malester,Mike Hutton,Jennifer Adamson,Michel Goedert,K. Burki,Peter Davies +11 more
TL;DR: A comparison between the genomic tau mice and mice that overexpress a tau cDNA transgene shows that overall, the distribution of tau is similar in the two lines, but human t Tau is located in the somatodendritic compartment of many neurons in the cDNA mice.