L
Loretta Müller
Researcher at University of Bern
Publications - 37
Citations - 1044
Loretta Müller is an academic researcher from University of Bern. The author has contributed to research in topics: Diesel exhaust & Immune system. The author has an hindex of 18, co-authored 37 publications receiving 931 citations. Previous affiliations of Loretta Müller include University of North Carolina at Chapel Hill & Bern University of Applied Sciences.
Papers
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Journal ArticleDOI
Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways
Loretta Müller,Michael Riediker,Peter Wick,Martin Mohr,Peter Gehr,Barbara Rothen-Rutishauser +5 more
TL;DR: The interplay of different lung cell types seems to substantially modulate the oxidative stress and the inflammatory responses after NP exposure, and in the triple cell co-cultures, the TAC and IL-8 concentrations were lower and the TNF-α concentrations were higher than the expected values calculated from the monocultures.
Journal ArticleDOI
Culturing of human nasal epithelial cells at the air liquid interface.
TL;DR: In vitro models of differentiated human nasal epithelial cells will enable investigators to address novel and important research questions by using organotypic experimental models that largely mimic the nasal epithelium in vivo.
Journal ArticleDOI
Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro.
Maria Helfenstein,Michele Miragoli,Stephan Rohr,Loretta Müller,Peter Wick,Martin Mohr,Peter Gehr,Barbara Rothen-Rutishauser +7 more
TL;DR: The results suggest that diesel exhaust as well as titanium dioxide particles and to a lesser extent also single-walled carbon nanotubes can directly induce cardiac cell damage and can affect the function of the cells.
Journal ArticleDOI
Comparison of the toxicity of diesel exhaust produced by bio- and fossil diesel combustion in human lung cells in vitro
Sandro Steiner,Jan Czerwinski,Pierre Comte,Olga Popovicheva,E. D. Kireeva,Loretta Müller,Norbert V. Heeb,Andreas Mayer,Alke Fink,Barbara Rothen-Rutishauser,Barbara Rothen-Rutishauser +10 more
TL;DR: In this article, a complex 3D cellular model of the human airway epithelium in vitro by exposing the cells at the air-liquid interface was assessed and the induction of pro-apoptotic and necrotic cell death, cellular morphology, oxidative stress, and pro-inflammatory responses were assessed.
Journal ArticleDOI
New Exposure System To Evaluate the Toxicity of (Scooter) Exhaust Emissions in Lung Cells in Vitro
Loretta Müller,Pierre Comte,Jan Czerwinski,Markus Kasper,Andreas Mayer,Peter Gehr,Heinz Burtscher,Jean-Paul Morin,Athanasios G. Konstandopoulos,Barbara Rothen-Rutishauser +9 more
TL;DR: It was shown that the described exposure system can be used to evaluate the toxic potential of total exhaust emissions and inflammatory chemo- and cytokine concentrations in the medium of exposed cells were significantly higher at the 12 h postexposure time point.