E
Emily Berghoff
Researcher at Howard Hughes Medical Institute
Publications - 10
Citations - 794
Emily Berghoff is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Nervous system & Microvesicles. The author has an hindex of 7, co-authored 10 publications receiving 597 citations. Previous affiliations of Emily Berghoff include Columbia University & Northwestern University.
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Journal ArticleDOI
Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method
Daniel Enderle,Alexandra Spiel,Christine M. Coticchia,Emily Berghoff,Romy Mueller,Martin Schlumpberger,Markus Sprenger-Haussels,Jonathan M Shaffer,Eric Lader,Johan Skog,Mikkel Noerholm +10 more
TL;DR: The development and characterization of a spin column-based method for the isolation of total RNA from EVs in serum and plasma that isolates highly pure RNA of equal or higher quantity compared to ultracentrifugation, with high specificity for vesicular over non-vesicular RNA.
Journal ArticleDOI
Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes.
TL;DR: A model in which Evf2 inhibits enhancer DNA methylation is proposed, effectively modulating competition between the DLX1/2 activator and MECP2 repressor proteins enables differential transcriptional control of adjacent genes with shared DNA regulatory elements.
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Detection of wild-Type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients
Javier M. Figueroa,Johan Karl Olov Skog,Johnny C. Akers,Hongying Li,Ricardo J. Komotar,Randy L. Jensen,Florian Ringel,Isaac Yang,Steven N. Kalkanis,Reid Thompson,Lori LoGuidice,Emily Berghoff,Andrew T. Parsa,Linda M. Liau,William T. Curry,Daniel P. Cahill,Chetan Bettegowda,Frederick F. Lang,E. Antonio Chiocca,John W. Henson,Ryan Y. Kim,Xandra O. Breakefield,Clark C. Chen,Karen Messer,Fred H. Hochberg,Bob S. Carter +25 more
TL;DR: The high specificity of the CSF-derived EV diagnostic test gives us an accurate determination of positive EGFRvIII tumor status and is essentially a less invasive "liquid biopsy" that might direct mutation-specific therapies for GBMs.
Journal ArticleDOI
Plasticity of the Electrical Connectome of C. elegans.
TL;DR: It is demonstrated that dauer-specific electrical synapse remodeling is responsible for specific aspects of the altered locomotory and chemosensory behavior of dauers.
Journal ArticleDOI
The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons.
Emily Berghoff,Lori Glenwinkel,Abhishek Bhattacharya,HaoSheng Sun,Erdem Varol,Nicki Mohammadi,Amelia Antone,Yi Feng,Ken Nguyen,Steven J. Cook,Jordan F. Wood,Neda Masoudi,Cyril Cros,Yasmin H Ramadan,Denise M. Ferkey,David H. Hall,Oliver Hobert +16 more
TL;DR: It is found that the Caenorhabditis elegans Prop1-like homeobox gene unc-42 is expressed in 15 distinct sensory, inter- and motor neuron classes throughout the entire C. elegans nervous system, and establishes functional circuitry by acting as a terminal selector of functionally connected neuron types.