P
Pei Hsuan Chen
Researcher at University of Texas Southwestern Medical Center
Publications - 13
Citations - 2085
Pei Hsuan Chen is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 8 publications receiving 1632 citations. Previous affiliations of Pei Hsuan Chen include Harvard University.
Papers
More filters
Journal ArticleDOI
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen,William W. Wheaton,Eunsook S. Jin,Pei Hsuan Chen,Lucas B. Sullivan,Tzuling Cheng,Youfeng Yang,W. Marston Linehan,Navdeep S. Chandel,Ralph J. DeBerardinis +9 more
TL;DR: These findings reveal the novel induction of a versatile glutamine-dependent pathway that reverses many of the reactions of the canonical CAC, supports tumour cell growth, and explains how cells generate pools of CAC intermediates in the face of impaired mitochondrial metabolism.
Journal ArticleDOI
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola,Pei Hsuan Chen,Edouard Mullarky,Jessica Sudderth,Zeping Hu,David Wu,Hao Tang,Yang Xie,John M. Asara,Kenneth E. Huffman,Ignacio I. Wistuba,John D. Minna,Ralph J. DeBerardinis,Lewis C. Cantley +13 more
TL;DR: It is found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione and nucleotide production and it is shown that expression of these genes confers poor prognosis in human NSCLC.
Journal ArticleDOI
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma
Ana Galan-Cobo,Piyada Sitthideatphaiboon,Xiao Qu,Alissa Poteete,Marlese Pisegna,Pan Tong,Pei Hsuan Chen,Lindsey K. Boroughs,Mirna Rodriguez,Winter Zhang,Francesco Parlati,Jing Wang,Varsha Gandhi,Ferdinandos Skoulidis,Ralph J. DeBerardinis,John D. Minna,John V. Heymach +16 more
TL;DR: Findings elucidate the adaptive advantage provided by KEAP1/NRF2 pathway activation in KL tumors and support clinical testing of glutaminase inhibitor in subsets of KRAS-mutant lung adenocarcinoma.
Journal ArticleDOI
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
Pei Hsuan Chen,Ling Cai,Kenneth E. Huffman,Chendong Yang,Jiyeon Kim,Brandon Faubert,Lindsey K. Boroughs,Bookyung Ko,Jessica Sudderth,Elizabeth A. McMillan,Luc Girard,Dong Chen,Michael Peyton,Misty D. Shields,Bo Yao,David S. Shames,Hyun Seok Kim,Brenda C. Timmons,Ikuo Sekine,Rebecca Britt,Stephanie Weber,Lauren Averett Byers,John V. Heymach,Jing Chen,Michael A. White,John D. Minna,Guanghua Xiao,Ralph J. DeBerardinis +27 more
TL;DR: This article quantified metabolic features, mostly from the 13C enrichment of molecules from central carbon metabolism, in over 80 non-small cell lung cancer (NSCLC) cell lines cultured under identical conditions.
Journal ArticleDOI
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
Deepak Menon,Darin Salloum,Elyssa Bernfeld,Elizabeth Gorodetsky,Alla Akselrod,Maria A. Frias,Jessica Sudderth,Pei Hsuan Chen,Ralph J. DeBerardinis,David A. Foster +9 more
TL;DR: This study reveals that mTOR also senses the presence of lipids via production of PA, a central metabolite for membrane phospholipid biosynthesis, and examines the impact of exogenously supplied fatty acids on mTOR in KRas-driven cancer cells, which are programmed to utilize exogenous lipids.