Ludwig Zichner

TL;DR: Biocompatibility studies of silk films (with or without covalently bound RGD) that were seeded with bone-marrow derived mesenchymal stem cells and cultured in vitro with human MSC suggest that purified degradable silk is biocompatible and the in vitro cell culture model gave inflammatory responses that were comparable to those observed in vivo.

TL;DR: It is suggested that osteogenesis in cultured MSC can be modulated by scaffold properties and flow environment.

TL;DR: The results suggest that RGD-silk scaffolds are particularly suitable for autologous bone tissue engineering, presumably because of their stable macroporous structure, tailorable mechanical properties matching those of native bone, and slow degradation.

TL;DR: PerOssal exhibits excellent properties regarding resorption, biocompatibility, and antibiotic release and calcium sulphate showed cytotoxic effects in two out of four tests.

TL;DR: Results suggest that silk scaffolds are particularly suitable for tissue engineering of cartilage starting from hMSC, presumably due to their high porosity, slow biodegradation, and structural integrity.