L
Luigi Warren
Researcher at Children's Medical Center of Dallas
Publications - 21
Citations - 3698
Luigi Warren is an academic researcher from Children's Medical Center of Dallas. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 11, co-authored 19 publications receiving 3473 citations. Previous affiliations of Luigi Warren include California Institute of Technology & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
Luigi Warren,Philip D. Manos,Philip D. Manos,Tim Ahfeldt,Tim Ahfeldt,Yuin-Han Loh,Hu Li,Hu Li,Frank H. Lau,Wataru Ebina,Pankaj Mandal,Zachary D. Smith,Alexander Meissner,Alexander Meissner,George Q. Daley,Andrew S. Brack,James J. Collins,James J. Collins,James J. Collins,Chad A. Cowan,Thorsten M. Schlaeger,Thorsten M. Schlaeger,Derrick J. Rossi +22 more
TL;DR: It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.
Journal ArticleDOI
Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
TL;DR: A systematic, quantitative population analysis of transcription factor expression within developmental progenitors, made possible by a microfluidic chip-based “digital RT-PCR” assay that can count template molecules in cDNA samples prepared from single cells is reported, which demonstrates caveats of normalizing expression data to endogenous controls and underscores the need to put gene measurement on an absolute, copy-per-cell basis.
Journal ArticleDOI
Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA
TL;DR: In this paper, a feeder-free, xeno-free protocol for mRNA-based iPSC derivation is presented. But, this protocol requires the use of feeder cells that add complexity and variability to the procedure while introducing a route for contamination with non-human-derived biological material.
Patent
Sustained polypeptide expression from synthetic, modified rnas and uses thereof
Derrick J. Rossi,Luigi Warren +1 more
TL;DR: In this paper, the authors describe methods, compositions, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells, such as expressing a polypeptide or altering the developmental potential.
Journal ArticleDOI
Stem cells and aging in the hematopoietic system.
Luigi Warren,Derrick J. Rossi +1 more
TL;DR: With age, HSCs show an increased propensity to differentiate towards myeloid rather than lymphoid lineages, which may contribute to the decline in lymphopoiesis that attends aging.