Hu Li

TL;DR: It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.

TL;DR: This in vitro model replicated results from past animal and human studies, including demonstration that probiotic and antibiotic therapies can suppress villus injury induced by pathogenic bacteria and proof-of-principle to show that the microfluidic gut-on-a-chip device can be used to create human intestinal disease models and gain new insights into gut pathophysiology.

TL;DR: Extended passage of some iPSC clones in culture did not improve their epigenetic resemblance to embryonic stem cells, implying that some human iPSCs retain a residual 'epigenetic memory' of their tissue of origin.

TL;DR: In this paper, the authors characterize transcriptional heterogeneity in Pluripotent Stem Cells (PSCs) by single-cell single-input single-out (SISO) experiments.

TL;DR: A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both T CR-β and TCR-γ rearrangement by PCR.