L
Luis de la Torre-Ubieta
Researcher at University of California, Los Angeles
Publications - 31
Citations - 4144
Luis de la Torre-Ubieta is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Regulation of gene expression & Genome-wide association study. The author has an hindex of 18, co-authored 31 publications receiving 3170 citations. Previous affiliations of Luis de la Torre-Ubieta include Harvard University.
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Journal ArticleDOI
Advancing the understanding of autism disease mechanisms through genetics
TL;DR: Current understanding of the genetic architecture of ASD is reviewed and genetic evidence, neuropathology and studies in model systems with how they inform mechanistic models of ASD pathophysiology are integrated.
Journal ArticleDOI
The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases
Shigeki Iwase,Fei Lan,Peter E. Bayliss,Luis de la Torre-Ubieta,Maite Huarte,Hank H. Qi,Johnathan R. Whetstine,Azad Bonni,Thomas M. Roberts,Yang Shi +9 more
TL;DR: A family of H3K4me3 demethylases are identified and a critical link between histone modifications and XLMR is uncovered, uncovering a role for SMCX in neuronal survival and dendritic development and a link to the demethylase activity.
Journal ArticleDOI
Chromosome conformation elucidates regulatory relationships in developing human brain
Hyejung Won,Luis de la Torre-Ubieta,Jason L. Stein,Neelroop N. Parikshak,Jerry Huang,Carli K. Opland,Michael J. Gandal,Gavin J. Sutton,Farhad Hormozdiari,Daning Lu,Changhoon Lee,Eleazar Eskin,Irina Voineagu,Jason Ernst,Daniel H. Geschwind +14 more
TL;DR: High-resolution 3D maps of chromatin contacts during human corticogenesis are generated, permitting large-scale annotation of previously uncharacterized regulatory relationships relevant to the evolution of human cognition and disease.
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A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.
Damon Polioudakis,Luis de la Torre-Ubieta,Justin Langerman,Andrew G. Elkins,Xu Shi,Jason L. Stein,Celine K. Vuong,Susanne Nichterwitz,Melinda Gevorgian,Melinda Gevorgian,Carli K. Opland,Daning Lu,William Connell,Elizabeth K. Ruzzo,Jennifer K. Lowe,Tarik Hadzic,Flora I. Hinz,Shan Sabri,William E. Lowry,Mark Gerstein,Kathrin Plath,Daniel H. Geschwind +21 more
TL;DR: This work ties cell-cycle progression with early cell fate decisions during neurogenesis, demonstrating that differentiation occurs on a transcriptomic continuum; rather than only expressing a few transcription factors that drive cell fates, differentiating cells express broad, mixed cell-type transcriptomes before telophase.
Journal ArticleDOI
The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis
Luis de la Torre-Ubieta,Jason L. Stein,Jason L. Stein,Hyejung Won,Carli K. Opland,Dan Liang,Daning Lu,Daniel H. Geschwind +7 more
TL;DR: It is observed that common genetic variants associated with educational attainment, risk for neuropsychiatric disease, and intracranial volume are enriched within regulatory elements involved in cortical neurogenesis, demonstrating the importance of this early developmental process for adult human cognitive function.