P
Peter E. Bayliss
Researcher at Harvard University
Publications - 13
Citations - 2325
Peter E. Bayliss is an academic researcher from Harvard University. The author has contributed to research in topics: Zebrafish & Senescence. The author has an hindex of 12, co-authored 12 publications receiving 2156 citations. Previous affiliations of Peter E. Bayliss include Princess Margaret Cancer Centre.
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Journal ArticleDOI
A histone H3 lysine 27 demethylase regulates animal posterior development.
Fei Lan,Peter E. Bayliss,John L. Rinn,Johnathan R. Whetstine,Jordon K. Wang,Shuzhen Chen,Shigeki Iwase,Roman Alpatov,Irina Issaeva,Eli Canaani,Thomas M. Roberts,Howard Y. Chang,Yang Shi +12 more
TL;DR: It is shown that the JmjC-domain-containing related proteins UTX and JMJD3 catalyse demethylation of H3K27me3/2, which identifies a small family of H 3K27 demethylases with important, evolutionarily conserved roles in H3k27 methylation regulation and in animal anterior–posterior development.
Journal ArticleDOI
The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases
Shigeki Iwase,Fei Lan,Peter E. Bayliss,Luis de la Torre-Ubieta,Maite Huarte,Hank H. Qi,Johnathan R. Whetstine,Azad Bonni,Thomas M. Roberts,Yang Shi +9 more
TL;DR: A family of H3K4me3 demethylases are identified and a critical link between histone modifications and XLMR is uncovered, uncovering a role for SMCX in neuronal survival and dendritic development and a link to the demethylase activity.
Journal ArticleDOI
Dissection of angiogenic signaling in zebrafish using a chemical genetic approach.
TL;DR: Overexpression of AKT/PKB, a putative effector of vascular endothelial growth factor signaling, allowed blood vessels to form in the presence of drug, thus establishing the physiological relevance of AKt/P KB in the angiogenic process.
Journal ArticleDOI
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish
Peter E. Bayliss,Kimberly L Bellavance,Geoffrey G. Whitehead,Joshua Abrams,Sandrine Aegerter,Heather S Robbins,Douglas B. Cowan,Mark T. Keating,Terence O'reilly,Jeanette Marjorie Wood,Thomas M. Roberts,Joanne Chan +11 more
TL;DR: The utility of the adult zebrafish as a new model system for receptor signaling and chemical biology is illustrated, as an angiogenic limit to tissue regeneration was determined, as avascular tissue containing skin, pigment, neuronal axons and bone precursors could regenerate up to about 1 mm.
Journal ArticleDOI
The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.
Shuji Kishi,Peter E. Bayliss,Junzo Uchiyama,Eriko Koshimizu,Eriko Koshimizu,Jie Qi,Jie Qi,Puru Nanjappa,Shintaro Imamura,Asiful Islam,Donna Neuberg,Adam Amsterdam,Thomas M. Roberts +12 more
TL;DR: In this article, the same authors used the same SA-β-gal assay to screen chemically mutagenized zebrafish, each of which was heterozygous for lesions in multiple genes, under the sensitizing conditions of oxidative stress.