L
Luis Meza
Researcher at University of Costa Rica
Publications - 8
Citations - 688
Luis Meza is an academic researcher from University of Costa Rica. The author has contributed to research in topics: Population & Linkage disequilibrium. The author has an hindex of 7, co-authored 8 publications receiving 684 citations.
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Journal ArticleDOI
Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23
Nelson B. Freimer,[No Value] Reus,Michael A. Escamilla,L A McInnes,Mitzi Spesny,Pedro León,Lauren B. Smith,Sandra Silva,Eugenia Ibarra Rojas,Alfred Gallegos,Luis Meza,Eduardo Fournier,Siamak Baharloo,Kathleen Blankenship,David J. Tyler,Steven L. Batki,Sophia Vinogradov,Jean Weissenbach,Samuel H. Barondes,LA Sandkuijl,LA Sandkuijl +20 more
TL;DR: A multistage study in the genetically isolated population of the Central Valley of Costa Rica to identify genes that promote susceptibility to severe BP (termed BPI), and screened the genome of two Costa Rican BPI pedigrees.
Journal ArticleDOI
A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees
L. Alison McInnes,Michael A. Escamilla,Victor I. Reus,Pedro León,Sandra Silva,Eugenia Ibarra Rojas,Mitzi Spesny,Siamak Baharloo,Kathleen Blankenship,Amy Peterson,David J. Tyler,Norito Shimayoshi,Christa Tobey,Steven L. Batki,Sophia Vinogradov,Luis Meza,Alvaro Gallegos,Eduardo Fournier,Lauren B. Smith,Samuel H. Barondes,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Nelson B. Freimer +23 more
TL;DR: The results of this genome screen for BP-I loci are reported and indicate several regions that merit further study, including segments in 18q, 18p, and 11p, in which suggestive lod scores were observed for two or more contiguous markers.
Journal ArticleDOI
Use of linkage disequilibrium approaches to map genes for bipolar disorder in the Costa Rican population
Michael A. Escamilla,Mitzi Spesny,Victor I. Reus,Alvaro Gallegos,Luis Meza,Julio Molina,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Eduardo Fournier,Pedro León,Lauren B. Smith,Nelson B. Freimer +12 more
TL;DR: The population of the Central Valley of Costa Rica, which is descended from a small number of founders, should be suitable for LD mapping; this assertion is supported by reconstruction of extended haplotypes shared by distantly related individuals in this population suffering low-frequency hearing loss.
Journal ArticleDOI
Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18.
Michael A. Escamilla,L. Alison McInnes,Mitzi Spesny,Victor I. Reus,Norito Shimayoshi,David J. Tyler,Sandra Silva,Julio Molina,Alvaro Gallegos,Luis Meza,Maria L. Cruz,Steven L. Batki,Sophia Vinogradov,Thomas C. Neylan,Jasmine B. Nguyen,Eduardo Fournier,Carmen Araya,Samuel H. Barondes,Pedro León,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Nelson B. Freimer +22 more
TL;DR: Investigation of the feasibility of LD methods for genome screening using a sample of individuals affected with severe bipolar mood disorder (BP-I), from an isolated population of the Costa Rican central valley suggests that LD methods will be useful for mapping BP-I in a larger sample.
Journal ArticleDOI
An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees
Nelson B. Freimer,Victor I. Reus,Michael A. Escamilla,Mitzi Spesny,Lauren B. Smith,Alfred Gallegos,Luis Meza,Steven L. Batki,Sophia Vinogradov,Pedro León,Lodewijk A. Sandkuijl +10 more
TL;DR: A strategy for mapping BP loci is described, focused on investigation of large pedigrees from a genetically homogenous population, that of Costa Rica, based on the use of a conservative definition of the BP phenotype in preparation for whole genome screening with polymorphic markers.