L
Luiz S. Ozaki
Researcher at New York University
Publications - 6
Citations - 377
Luiz S. Ozaki is an academic researcher from New York University. The author has contributed to research in topics: Gene & Plasmodium knowlesi. The author has an hindex of 5, co-authored 6 publications receiving 373 citations. Previous affiliations of Luiz S. Ozaki include National Institutes of Health.
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Journal ArticleDOI
Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein
TL;DR: The gene that codes for the surface antigen of Plasmodium knowlesi sporozoites (CS protein) is unsplit and present in the genome in only one copy, indicating that the parasite promoter and ribosome binding site signals can be recognized in E. coli.
Journal ArticleDOI
Cloning and expression in E. coli of the malarial sporozoite surface antigen gene from Plasmodium knowlesi
Joan Ellis,Joan Ellis,Luiz S. Ozaki,Luiz S. Ozaki,R. W. Gwadz,R. W. Gwadz,Alan H. Cochrane,Alan H. Cochrane,Victor Nussenzweig,Victor Nussenzweig,Ruth S. Nussenzweig,Ruth S. Nussenzweig,G. Nigel Godson,G. Nigel Godson +13 more
TL;DR: This work has isolated a clone that expresses the sporozoite surface antigen as a β-lactamase fusion protein in the plasmid pBR322, the first potentially protective malarial antigen to be cloned by recombinant DNA technology.
Journal ArticleDOI
Specificity of Tn5 insertions into a 36-bp DNA sequence repeated in tandem seven times
TL;DR: The target junction sequences of six independent Tn5 insertions into a 36-bp tandemly repeated DNA segment have been determined and imply that, even though Tn 5 appears to insert randomly on a macro scale, at the nucleotide sequence level insertion into target DNA, which has limited similarity to the Tn4 end reactive sequences, may be a preferred event.
Journal ArticleDOI
Structure and Organization of Genes for Sporozoite Surface Antigens
TL;DR: The major surface antigen (circumsporozoite-protein) of the sporozoite stage of Plasmodium knowlesi has been cloned and characterized and the gene is notable for the presence of a 36 base pair unit repeated in tandem 12 times.
Journal ArticleDOI
Localization of a Plasmodium surface antigen epitope by Tn5 mutagenesis mapping of a recombinant cDNA clone.
TL;DR: A recombinant complementary DNA clone from Plasmodium knowlesi makes a beta-lactamase fusion polypeptide in Escherichia coli that reacts with a monoclonal antibody to a PlasModium surface antigen that was localized by transposon Tn5 mutagenesis mapping of the complementaryDNA clone.