Lutgardis Gabriëls

TL;DR: Combined long-term results of DBS studies show that the procedure can be successfully implemented by dedicated interdisciplinary teams, and support its therapeutic promise, and suggest that neural networks relevant to therapeutic improvement might be modulated more effectively at a more posterior target.

TL;DR: Investigation of deep brain stimulation (DBS) as a last‐resort treatment alternative to capsulotomy in treatment‐refractory obsessive‐compulsive disorder (OCD).

TL;DR: The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures.

TL;DR: Observations provide evidence that the subgenual anterior cingulate and ventral striatum have a key role in the neuronal circuitry involved in the pathophysiology of OCD with associated major depression and in the neuromodulatory mechanism of anterior capsular stimulation.

TL;DR: Anterior capsular stimulation induces some improvement in severe treatment-resistant OCD patients, and the effects are a valuable source for further neurophysiologic and neuroanatomic research.