L
Lutz Müller-Kuhrt
Publications - 4
Citations - 285
Lutz Müller-Kuhrt is an academic researcher. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Peroxisome proliferator-activated receptor gamma. The author has an hindex of 3, co-authored 4 publications receiving 243 citations.
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Journal ArticleDOI
Amorfrutins are potent antidiabetic dietary natural products
Christopher Weidner,Jens C. de Groot,Aman Prasad,Anja Freiwald,Claudia Quedenau,Magdalena Kliem,Annabell Witzke,Vitam Kodelja,Chung-Ting Han,Sascha Giegold,Matthias Baumann,Bert Klebl,Karsten Siems,Lutz Müller-Kuhrt,Annette Schürmann,Rita Schüler,Andreas Pfeiffer,Frank C. Schroeder,Konrad Büssow,Sascha Sauer +19 more
TL;DR: In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity.
Journal ArticleDOI
Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties
Christopher Weidner,Sylvia J. Wowro,Anja Freiwald,K. Kawamoto,Annabell Witzke,Magdalena Kliem,Karsten Siems,Lutz Müller-Kuhrt,Frank C. Schroeder,Sascha Sauer +9 more
TL;DR: In insulin-resistant mice, amorfrutin B considerably improved insulin sensitivity, glucose tolerance and blood lipid variables after several days of treatment, and had no adverse effects on osteoblastogenesis and fluid retention.
Journal ArticleDOI
Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.
Christophe Antczak,Carolyn Kloepping,Constantin Radu,Thorsten Genski,Lutz Müller-Kuhrt,Karsten Siems,Elisa de Stanchina,David H. Abramson,Hakim Djaballah +8 more
TL;DR: Cardenolides were identified as a new class of antitumor agents for the treatment of retinoblastoma if administered locally via direct intra-arterial infusion.
Journal ArticleDOI
An ADH toolbox for raspberry ketone production from natural resources via a biocatalytic cascade.
Aileen Becker,Dominique Böttcher,Werner Katzer,Karsten Siems,Lutz Müller-Kuhrt,Uwe T. Bornscheuer +5 more
TL;DR: In this article, a toolbox for Raspberry ketone production using a combination of (R)- and (S)-selective alcohol dehydrogenases together with a universal cofactor recycling system is presented.