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Claudia Quedenau
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 25
Citations - 1928
Claudia Quedenau is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Medicine & Human leukocyte antigen. The author has an hindex of 14, co-authored 21 publications receiving 1497 citations. Previous affiliations of Claudia Quedenau include Max Planck Society.
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Journal ArticleDOI
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Xintian You,Irena Vlatkovic,Ana Babic,Tristan J. Will,Irina Epstein,Georgi Tushev,Güney Akbalik,Mantian Wang,Caspar Glock,Claudia Quedenau,Xi Wang,Jingyi Hou,Hongyu Liu,Wei Sun,Sivakumar Sambandan,Tao Chen,Erin M. Schuman,Wei Chen +17 more
TL;DR: The data indicate that brain circRNAs are positioned to respond to and regulate synaptic function and exhibited substantial up- or downregulation following a homeostatic downscaling of neuronal activity.
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Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
Weike Pei,Thorsten B. Feyerabend,Jens Rössler,Xi Wang,Daniel Postrach,Katrin Busch,Immanuel Rode,Kay Klapproth,Nikolaus Dietlein,Claudia Quedenau,Wei Chen,Sascha Sauer,Stephan Wolf,Thomas Höfer,Thomas Höfer,Hans Reimer Rodewald +15 more
TL;DR: The development of an artificial DNA recombination locus (termed Polylox) is reported that enables broadly applicable endogenous barcoding based on the Cre–loxP recombination system and reaches a practical diversity of several hundred thousand barcodes, allowing tagging of single cells.
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Amorfrutins are potent antidiabetic dietary natural products
Christopher Weidner,Jens C. de Groot,Aman Prasad,Anja Freiwald,Claudia Quedenau,Magdalena Kliem,Annabell Witzke,Vitam Kodelja,Chung-Ting Han,Sascha Giegold,Matthias Baumann,Bert Klebl,Karsten Siems,Lutz Müller-Kuhrt,Annette Schürmann,Rita Schüler,Andreas Pfeiffer,Frank C. Schroeder,Konrad Büssow,Sascha Sauer +19 more
TL;DR: In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity.
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Integrative analysis revealed the molecular mechanism underlying RBM10‐mediated splicing regulation
Yongbo Wang,Andreas Gogol-Döring,Hao Hu,Sebastian Fröhler,Yunxia Ma,Marvin Jens,Jonas Maaskola,Yasuhiro Murakawa,Claudia Quedenau,Markus Landthaler,Vera M. Kalscheuer,Dagmar Wieczorek,Yang Wang,Yuhui Hu,Wei Chen +14 more
TL;DR: RBM10 is established as an important regulator of alternative splicing, presented a mechanistic model for RBM10‐mediated splicing regulation and provided a molecular link to understanding a human congenital disorder.
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Pervasive isoform‐specific translational regulation via alternative transcription start sites in mammals
TL;DR: This study demonstrated the extensive translational regulation by usage of alternative transcription start sites and offered comprehensive understanding of translationalregulation by diverse sequence features embedded in 5ʹUTRs.