M
Magdalena Kliem
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 17
Citations - 976
Magdalena Kliem is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Mass spectrometry & Resveratrol. The author has an hindex of 8, co-authored 17 publications receiving 814 citations. Previous affiliations of Magdalena Kliem include Max Planck Society.
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Journal ArticleDOI
Mass spectrometry tools for the classification and identification of bacteria
Sascha Sauer,Magdalena Kliem +1 more
TL;DR: Recently, several mass spectrometry methods for the classification and identification of bacteria and other microorganisms, as well as new software analysis tools, have been developed and their potential for transfer into microbiology laboratories are discussed.
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Amorfrutins are potent antidiabetic dietary natural products
Christopher Weidner,Jens C. de Groot,Aman Prasad,Anja Freiwald,Claudia Quedenau,Magdalena Kliem,Annabell Witzke,Vitam Kodelja,Chung-Ting Han,Sascha Giegold,Matthias Baumann,Bert Klebl,Karsten Siems,Lutz Müller-Kuhrt,Annette Schürmann,Rita Schüler,Andreas Pfeiffer,Frank C. Schroeder,Konrad Büssow,Sascha Sauer +19 more
TL;DR: In diet-induced obese and db/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity.
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Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart
Ramon Vidal,Julian U. G. Wagner,Caroline Braeuning,Cornelius Fischer,Ralph Patrick,Ralph Patrick,Lukas Tombor,Marion Muhly-Reinholz,David John,Magdalena Kliem,Thomas Conrad,Nuno Guimarães-Camboa,Richard P. Harvey,Richard P. Harvey,Stefanie Dimmeler,Stefanie Dimmeler,Sascha Sauer +16 more
TL;DR: This study provides system-wide insights and identifies molecular changes of aging cardiac fibroblasts, which may contribute to declined heart function and be significantly prevented by using neutralizing antibodies.
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Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Annabell Plauth,Anne Geikowski,Susanne Cichon,Sylvia J. Wowro,Linda Liedgens,Morten Rousseau,Christopher Weidner,Luise Fuhr,Magdalena Kliem,Gail Jenkins,Silvina Lotito,Linda Jane Wainwright,Sascha Sauer,Sascha Sauer,Sascha Sauer +14 more
TL;DR: It is demonstrated that under physiologically relevant conditions major biological effects of resveratrol can be attributed to its generation of oxidation products such as reactive oxygen species (ROS) and proposed that the cellular response to resver atrol treatment is essentially based on oxidative triggering.
Journal ArticleDOI
The essence on mass spectrometry based microbial diagnostics.
Magdalena Kliem,Sascha Sauer +1 more
TL;DR: The matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) has become an important bioanalytical method to detect profiles of proteins and peptides derived from whole bacterial cells as mentioned in this paper.