L
Luzie Merten
Researcher at University of Mainz
Publications - 1
Citations - 89
Luzie Merten is an academic researcher from University of Mainz. The author has contributed to research in topics: Humanized mouse & Natural killer cell. The author has an hindex of 1, co-authored 1 publications receiving 78 citations.
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Interferon-α Suppresses cAMP to Disarm Human Regulatory T Cells
Nicole Bacher,Verena Raker,Claudia Hofmann,Edith Graulich,Melanie Schwenk,Ria Baumgrass,Tobias Bopp,Ulrich Zechner,Luzie Merten,Christian Becker,Kerstin Steinbrink +10 more
TL;DR: It is shown that IFN-α deactivates the suppressive function of human Treg by downregulating their intracellular cAMP level, which provides a conceivable explanation for the immune-promoting effect and induction of autoimmunity by IFn-α treatment in patients with cancer and suggestsIFN- α for concomitant Treg blockade in the context of therapeutic vaccination against tumor antigens.