R
Ria Baumgrass
Researcher at Leibniz Association
Publications - 65
Citations - 2319
Ria Baumgrass is an academic researcher from Leibniz Association. The author has contributed to research in topics: Calcineurin & NFAT. The author has an hindex of 25, co-authored 60 publications receiving 2110 citations. Previous affiliations of Ria Baumgrass include University of Potsdam & Max Planck Society.
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Journal ArticleDOI
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
Anna-Barbara Stittrich,Claudia Haftmann,Evridiki Sgouroudis,Anja A. Kühl,Ahmed N. Hegazy,Isabel Panse,René Riedel,Michael Flossdorf,Jun Dong,Franziska Fuhrmann,Gitta Anne Heinz,Zhuo Fang,Na Li,Ute Bissels,Farahnaz Hatam,Angelina Jahn,Ben Hammoud,Mareen Matz,Felix Michael Schulze,Ria Baumgrass,Andreas Bosio,Hans-Joachim Mollenkopf,Joachim R. Grün,Andreas Thiel,Wei Chen,Thomas Höfer,Christoph Loddenkemper,Max Löhning,Hyun-Dong Chang,Nikolaus Rajewsky,Andreas Radbruch,Mir-Farzin Mashreghi +31 more
TL;DR: A central role for miR-182 is demonstrated in the physiological regulation of IL-2-driven helper T cell–mediated immune responses and new therapeutic possibilities are opened.
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Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Julia K. Polansky,Lisa Schreiber,Christoph Thelemann,Leif S. Ludwig,Melanie Krüger,Ria Baumgrass,Sascha Cording,Stefan Floess,Alf Hamann,Jochen Huehn +9 more
TL;DR: It is proposed that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage.
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Autoregulation of Th1-mediated inflammation by twist1
Uwe Niesner,Inka Albrecht,Marko Janke,Cornelia Doebis,Christoph Loddenkemper,Maria H. Lexberg,Katharina Eulenburg,Stephan Kreher,Juliana Koeck,Ria Baumgrass,Kerstin Bonhagen,Thomas Kamradt,Philipp Enghard,Jens Y Humrich,Sascha Rutz,Ulf Schulze-Topphoff,Orhan Aktas,Sina Bartfeld,Helena Radbruch,Ahmed N. Hegazy,Max Löhning,Daniel C. Baumgart,Rainer Duchmann,Martin Rudwaleit,Thomas Häupl,Inna Gitelman,Veit Krenn,Joachim Gruen,J. Sieper,Martin Zeitz,Bertram Wiedenmann,Frauke Zipp,Alf Hamann,Michal Janitz,Alexander Scheffold,Gerd R Burmester,Hyun D. Chang,Andreas Radbruch +37 more
TL;DR: In this paper, the basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology.
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A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Florian Schulz,Ingo Marenholz,Regina Fölster-Holst,Christiane Chen,Alexander Sternjak,Ria Baumgrass,Jorge Esparza-Gordillo,Christoph Grüber,Renate Nickel,Stefan Schreiber,Monika Stoll,Michael Kurek,Franz Rüschendorf,Norbert Hubner,Ulrich Wahn,Young-Ae Lee +15 more
TL;DR: This study presents the first genetic risk factor for the nonatopic type of eczema and indicates a primary role of IL-31-induced pruritus in the initiation of this disease, thus proposing a new target for the prevention and therapy of Eczema.
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Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
Matthias Sieber,Ria Baumgrass +1 more
TL;DR: This review summarizes the current knowledge about novel inhibitors, synthesized or identified in the last decades, and focus on their mode of action, specificity, and biological effects.