Ulrich Zechner

TL;DR: It is suggested that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.

TL;DR: This approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility.

TL;DR: The analysis shows that conservation of synteny between human and pig is three times more than between humans and mice and, consequently, is characterized by fewer, but larger conserved segments.

TL;DR: The findings indicate that compared with the autosomes, the X chromosome contains a significantly higher number of genes that, when mutated, cause mental impairment and it is proposed that these genes are involved in the development of cognitive abilities and thus exert a large X-chromosome effect on general intelligence in humans.

TL;DR: A model in which SHARP is a novel component of the HDAC corepressor complex, recruited by RBP‐Jκ to repress transcription of target genes in the absence of activated Notch is proposed.