M
Melanie Schwenk
Researcher at University of Mainz
Publications - 6
Citations - 783
Melanie Schwenk is an academic researcher from University of Mainz. The author has contributed to research in topics: Angiotensin II & Immune system. The author has an hindex of 6, co-authored 6 publications receiving 670 citations.
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Journal ArticleDOI
Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Philip Wenzel,Maike Knorr,Sabine Kossmann,Jan Stratmann,Michael Hausding,Swenja Schuhmacher,Susanne Karbach,Melanie Schwenk,Nir Yogev,Eberhard Schulz,Matthias Oelze,Stephan Grabbe,Helmut Jonuleit,Christian Becker,Andreas Daiber,Ari Waisman,Thomas Münzel +16 more
TL;DR: Infiltrating monocytes with a proinflammatory phenotype and macrophages rather than neutrophils appear to be essential for ATII-induced vascular dysfunction and arterial hypertension.
Journal ArticleDOI
Angiotensin II–Induced Vascular Dysfunction Depends on Interferon-γ–Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells
Sabine Kossmann,Melanie Schwenk,Michael Hausding,Susanne Karbach,Maria I. Schmidgen,Moritz Brandt,Maike Knorr,Hanhan Hu,Swenja Kröller-Schön,Tanja Schönfelder,Stephan Grabbe,Matthias Oelze,Andreas Daiber,Thomas Münzel,Christian Becker,Philip Wenzel +15 more
TL;DR: First evidence that NK-cells play an essential role in ATII-induced vascular dysfunction is provided, and the T-bet-IFN-&ggr; pathway and mutual monocyte–NK-cell activation as potential therapeutic targets in cardiovascular disease are disclosed.
Journal ArticleDOI
Interferon-α Suppresses cAMP to Disarm Human Regulatory T Cells
Nicole Bacher,Verena Raker,Claudia Hofmann,Edith Graulich,Melanie Schwenk,Ria Baumgrass,Tobias Bopp,Ulrich Zechner,Luzie Merten,Christian Becker,Kerstin Steinbrink +10 more
TL;DR: It is shown that IFN-α deactivates the suppressive function of human Treg by downregulating their intracellular cAMP level, which provides a conceivable explanation for the immune-promoting effect and induction of autoimmunity by IFn-α treatment in patients with cancer and suggestsIFN- α for concomitant Treg blockade in the context of therapeutic vaccination against tumor antigens.
Journal ArticleDOI
Lysozyme M positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction
Sabine Kossmann,Maike Knorr,Jan Stratmann,Michael Hausding,Swenja Schuhmacher,Susanne Karbach,Melanie Schwenk,Nir Yogev,Eberhard Schulz,Matthias Oelze,Stephan Grabbe,Helmut Jonuleit,Christian Becker,Andreas Daiber,Ari Waisman,Thomas Münzel,Philip Wenzel +16 more
Journal ArticleDOI
CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction
Michael Hausding,Kerstin Jurk,Steffen Daub,Swenja Kröller-Schön,Judith Stein,Melanie Schwenk,Matthias Oelze,Yuliya Mikhed,Jasmin Ghaemi Kerahrodi,Sabine Kossmann,Thomas Jansen,Eberhard Schulz,Philip Wenzel,Angelika B. Reske-Kunz,Christian Becker,Thomas Münzel,Stephan Grabbe,Andreas Daiber +17 more
TL;DR: It is demonstrated that many ATII-induced effects on vascular dysfunction, such as vascular inflammation, oxidative stress and a pro-thrombotic state, are mediated at least in part via CD40L.