M
M B K Lambros
Researcher at The Breast Cancer Research Foundation
Publications - 15
Citations - 1303
M B K Lambros is an academic researcher from The Breast Cancer Research Foundation. The author has contributed to research in topics: Cancer & Chromogenic in situ hybridization. The author has an hindex of 10, co-authored 15 publications receiving 1205 citations.
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Journal ArticleDOI
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.
Nicholas C. Turner,M B K Lambros,Hugo M. Horlings,Alex Pearson,Rachel Sharpe,Rachael Natrajan,Felipe C. Geyer,M. van Kouwenhove,Bas Kreike,Alan Mackay,Alan Ashworth,M.J. van de Vijver,Jorge S. Reis-Filho +12 more
TL;DR: It is demonstrated that TNBCs are heterogeneous tumours with amplifications of FGFR2 in a subgroup of tumours.
Journal ArticleDOI
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas
Jorge S. Reis-Filho,Céline Pinheiro,M B K Lambros,Fernanda Milanezi,Fernanda Milanezi,Silvia Carvalho,Kay Savage,Peter T. Simpson,Chris Jones,Sally Swift,Alan Mackay,Rui Manuel Reis,Jason L. Hornick,Emílio M. Pereira,Fátima Baltazar,Christopher D.M. Fletcher,Alan Ashworth,Sunil R. Lakhani,Fernando Schmitt +18 more
TL;DR: It is indicated that further studies are warranted to explore EGFR tyrosine kinase inhibitors as potential therapeutic agents for metaplastic breast carcinomas harbouring amplification of 7p11.2.
Journal ArticleDOI
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
Peter T. Simpson,Peter T. Simpson,Jorge S. Reis-Filho,M B K Lambros,Chris Jones,Dawn Steele,Alan Mackay,Marjan Iravani,Kerry Fenwick,Tim Dexter,Allison Jones,Lynne Reid,L Da Silva,Sandra J. Shin,David Hardisson,Alan Ashworth,Fernando Schmitt,J Palacios,Sunil R. Lakhani +18 more
TL;DR: Molecular alterations found in PLC that are more typical of high‐grade IDC than ILC (p53 and HER2 positivity, 8q+, 17q24‐q25+, 13q− and amplification of 8q24, 12q14, 17q12 and 20q13) are likely to drive the high‐ grade and more aggressive biology of PLC.
Journal ArticleDOI
Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast
Caterina Marchiò,Caterina Marchiò,Marjan Iravani,Rachael Natrajan,M B K Lambros,Kay Savage,Narinder Tamber,Kerry Fenwick,Alan Mackay,Rebecca Senetta,S. Di Palma,Fernando Schmitt,Giovanni Bussolati,Ian O. Ellis,Alan Ashworth,Anna Sapino,Jorge S. Reis-Filho +16 more
TL;DR: It is demonstrated that pure invasive micropapillary carcinoma have distinct histological features and molecular genetic profiles supporting the contention that they constitute a distinct pathological entity.
Journal ArticleDOI
Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas
Olga Martinho,Adhemar Longatto-Filho,Adhemar Longatto-Filho,M B K Lambros,Albino Martins,Céline Pinheiro,Aline Bomfim Silva,Fernando Pardal,Júlia Amorim,Alan Mackay,Fernanda Milanezi,Narinder Tamber,Kerry Fenwick,Alan Ashworth,Jorge S. Reis-Filho,José Manuel Lopes,Rui Manuel Reis +16 more
TL;DR: The concurrent expression of PDGFA and PDGFRA in different subtypes of glioma, reinforce the recognised significance of this signalling pathway in gliomas.