M
M. D'Asaro
Researcher at University of Palermo
Publications - 12
Citations - 1339
M. D'Asaro is an academic researcher from University of Palermo. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 7, co-authored 11 publications receiving 1220 citations.
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Journal ArticleDOI
Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
Francesco Dieli,David Vermijlen,Fabio Fulfaro,Nadia Caccamo,Serena Meraviglia,Giuseppe Cicero,Andrew Roberts,Simona Buccheri,M. D'Asaro,Nicola Gebbia,Alfredo Salerno,Matthias Eberl,Adrian Hayday +12 more
TL;DR: Zoledronate + IL-2 represents a novel, safe, and feasible approach to induce immunologic and clinical responses in patients with metastatic carcinomas, potentially providing a substantially increased window for specific approaches to be administered.
Journal ArticleDOI
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
Serena Meraviglia,Matthias Eberl,David Vermijlen,Matilde Todaro,Simona Buccheri,Giuseppe Cicero,C. La Mendola,Giuliana Guggino,M. D'Asaro,Valentina Orlando,Francesco Scarpa,Andrew Roberts,Nadia Caccamo,Giorgio Stassi,Francesco Dieli,Adrian Hayday +15 more
TL;DR: The data emphasize the strong linkage of Vγ9Vδ2 T cell status to reduced carcinoma progression, and suggest that zoledronate plus low‐dose IL‐2 offers a novel, safe and feasible approach to enhance this in a subset of treatment‐refractory patients with advanced breast cancer.
Journal ArticleDOI
Efficient Killing of Human Colon Cancer Stem Cells by γδ T Lymphocytes
Matilde Todaro,M. D'Asaro,Nadia Caccamo,Flora Iovino,Maria Giovanna Francipane,Serena Meraviglia,Valentina Orlando,Carmela La Mendola,Gaspare Gulotta,Alfredo Salerno,Francesco Dieli,Giorgio Stassi +11 more
TL;DR: It is concluded that intentional activation of Vγ9Vδ2 T cells by zoledronate may substantially increase antitumor activities and represent a novel strategy for colon cancer immunotherapy.
Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes
Flora Iovino,Carmela La Mendola,Matilde Todaro,Serena Meraviglia,Gaspare Gulotta,Francesco Dieli,Giorgio Stassi,Alfredo Salerno,Nadia Caccamo,Maria Giovanna Francipane,M. D'Asaro,Valentina Orlando +11 more
Journal ArticleDOI
V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenous leukemia cells.
M. D'Asaro,Carmela La Mendola,Diana Di Liberto,Valentina Orlando,Matilde Todaro,Marisa Spina,Giuliana Guggino,Serena Meraviglia,Nadia Caccamo,Angelo Messina,Alfredo Salerno,Francesco Di Raimondo,Paolo Vigneri,Giorgio Stassi,Jean-Jacques Fournié,Francesco Dieli +15 more
TL;DR: It is concluded that intentional activation of Vγ9Vδ2 T cells by zoledronate may substantially increase their antileukemia activities and represent a novel strategy for CML immunotherapy.