Nicola Gebbia

TL;DR: Signal transducers and activators of transcription (STAT) proteins comprise a family of transcription factors latent in the cytoplasm that participate in normal cellular events, such as differentiation, proliferation, cell survival, apoptosis, and angiogenesis following cytokine, growth factor, and hormone signaling.

TL;DR: Zoledronate + IL-2 represents a novel, safe, and feasible approach to induce immunologic and clinical responses in patients with metastatic carcinomas, potentially providing a substantially increased window for specific approaches to be administered.

TL;DR: Analysis of TP53 mutations from a large cohort of CRC patients has identified tumor site, type of mutation, and adjuvant treatment as important factors in determining the prognostic significance of this genetic alteration.

TL;DR: Bisphosphonates are analogues of endogenous pyrophosphate in which a carbon atom replaces the central atom of oxygen and this carbon substitution makes these compounds resistant to hydrolysis and allows 2 additional chains of variable structure.

TL;DR: It is demonstrated, for the first time, that the VEGF expression in breast cancer cells is mediated by HIF‐1 and STAT3 in a miR‐20b‐dependent manner.