M. Derchansky

TL;DR: Results of in vitro experimental recordings from intact mouse hippocampus validate the circuit design and the on-chip electrode bonding technology.

TL;DR: The analysis showed that in certain cases, the transitions between ictal and interictal states can be modeled by a Poisson process operating in a bistable network.

TL;DR: There is a change in the interaction between afferent synaptic inhibition, and afferent and intrinsic excitatory processes in pyramidal neurons and interneurons, with maintained inhibition and increasing, entrained ‘overpowering’ excitation during the transition to seizure.

TL;DR: Using multisite electrophysiological recordings in two seizure models and voltage-sensitive dye imaging, spatiotemporally characterize the initiation and propagation of seizures in an intact epileptogenic brain region, the isolated hippocampus, revealing that the current concept of a single seizure "focus" is complex.

TL;DR: The proseizure effect of morphine is mediated through selective stimulation of &mgr; and &kgr; opiate receptors but not the activation of the &dgr; receptor system, which underscores careful adjustment and individualized opioid dosing in the clinical setting.