M
M. S. Wiesener
Researcher at John Radcliffe Hospital
Publications - 3
Citations - 871
M. S. Wiesener is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 3, co-authored 3 publications receiving 854 citations.
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Journal ArticleDOI
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
M. S. Wiesener,H. Turley,H. Turley,William Allen,William Allen,C. Willam,C. Willam,Kai-Uwe Eckardt,Kai-Uwe Eckardt,K.L. Talks,K.L. Talks,S.M. Wood,S.M. Wood,K.C. Gatter,K.C. Gatter,A.L. Harris,A.L. Harris,Christopher W. Pugh,Christopher W. Pugh,Peter J. Ratcliffe,Peter J. Ratcliffe,P. H. Maxwell,P. H. Maxwell +22 more
TL;DR: Functional studies in a mutant cell line expressing neither HIF-1alpha nor EPAS-1 confirmed that both proteins interact with hypoxically responsive targets, but suggest target specificity with greater EPas-1 transactivation of the VEGF promoter than the LDH-A promoter.
Journal ArticleDOI
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
S M Wood,M. S. Wiesener,K. M. Yeates,N Okada,Christopher W. Pugh,Patrick H. Maxwell,Peter J. Ratcliffe +6 more
TL;DR: The utility of mutagenesis and selection of mutant cells in the analysis of mammalian transcriptional responses to hypoxia is shown and the operation of HIF-1alpha-dependent and Hif-1 alpha-independent pathways of hypoxIA-inducible gene expression in Chinese hamster ovary cells is demonstrated.
Journal Article
Regulation of gene expression by oxygen levels in mammalian cells.
Christopher W. Pugh,G. W. Chang,Matthew Edward Cockman,A. C. R. Epstein,Jonathan M. Gleadle,Patrick H. Maxwell,L. G. Nicholls,J F O'Rourke,Peter J. Ratcliffe,E. C. Raybould,Ya-Min Tian,M. S. Wiesener,M. Wood,Charles C. Wykoff,K. M. Yeates +14 more