M
Madapura M. Pradeepa
Researcher at University of Edinburgh
Publications - 30
Citations - 1352
Madapura M. Pradeepa is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Histone & Histone code. The author has an hindex of 13, co-authored 23 publications receiving 1123 citations. Previous affiliations of Madapura M. Pradeepa include Queen Mary University of London & Jawaharlal Nehru Centre for Advanced Scientific Research.
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Journal ArticleDOI
Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing
TL;DR: The PWWP domain of the chromatin-associated protein Psip1/Ledgf can specifically recognize tri-methylated H3K36 and that, like this histone modification, thePsip1 short (p52) isoform is enriched at active genes.
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Histone H3 globular domain acetylation identifies a new class of enhancers
Madapura M. Pradeepa,Madapura M. Pradeepa,Graeme R. Grimes,Yatendra Kumar,Gabrielle Olley,Gillian C.A. Taylor,Robert Schneider,Wendy A. Bickmore +7 more
TL;DR: A more comprehensive analysis of histone acetylation is required than has previously been considered, and a new class of active functional enhancers is found that is marked by H3K122ac but lacks H 3K27ac.
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H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction
Gillian C.A. Taylor,Ragnhild Eskeland,Betul Hekimoglu-Balkan,Madapura M. Pradeepa,Wendy A. Bickmore +4 more
TL;DR: It is shown that loss of H4K16 acetylation does not alter higher-order chromatin compaction in vivo in mouse embryonic stem cells (ESCs), and that some enhancers are marked by H3K4me1, KAT8, and H4k16ac, but not by acetylated H3k27 or EP300, suggesting that they are novel EP300 independent regulatory elements.
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The E3 ubiquitin ligase activity of Ring1B is not essential for early mouse development
Robert S. Illingworth,Michael Moffat,Abigail R Mann,David Read,Chris J. Hunter,Madapura M. Pradeepa,Ian R. Adams,Wendy A. Bickmore +7 more
TL;DR: It is shown that the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity ofPRC1 is removed.
Journal ArticleDOI
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway
Kevin A. Robertson,Wei Yuan Hsieh,Thorsten Forster,Mathieu Blanc,Mathieu Blanc,Hongjin Lu,Peter J. Crick,Eylan Yutuc,Steven Watterson,Steven Watterson,Kim Martin,Samantha J. Griffiths,Anton J. Enright,Mami Yamamoto,Madapura M. Pradeepa,Kim A. Lennox,Mark A. Behlke,Simon G. Talbot,Jürgen Haas,Lars Dölken,Lars Dölken,William J. Griffiths,Yuqin Wang,Ana Angulo,Peter Ghazal +24 more
TL;DR: It is shown that miR-342-5p exerts broad antiviral effects against multiple, unrelated pathogenic viruses such Cytomegalovirus and Influenza A (H1N1).