抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

https://iopscience.iop.org/article/10.1088/0031-9112/34/4/040/pdf

Stochastic Processes in Physics and Chemistry

Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves

The Strategy of the Genes

A drop hitting a solid surface can deposit, bounce, or splash. Splashing arises from the breakup of a fine liquid sheet that is ejected radially along the substrate. Bouncing and deposition depend crucially on the wetting properties of the substrate. In this review, we focus on recent experimental and theoretical studies, which aim at unraveling the underlying physics, characterized by the delicate interplay of not only liquid inertia, viscosity, and surface tension, but also the surrounding gas. The gas cushions the initial contact; it is entrapped in a central microbubble on the substrate; and it promotes the so-called corona splash, by lifting the lamella away from the solid. Particular attention is paid to the influence of surface roughness, natural or engineered to enhance repellency, relevant in many applications.

https://hal.archives-ouvertes.fr/hal-01398138/document

Drop Impact on a Solid Surface

Young's law predicts that a colloidal sphere in equilibrium with a liquid interface will straddle the two fluids, its height above the interface defined by an equilibrium contact angle. This has been used to explain why colloids often bind to liquid interfaces, and has been exploited in emulsification, water purification, mineral recovery, encapsulation and the making of nanostructured materials. However, little is known about the dynamics of binding. Here we show that the adsorption of polystyrene microspheres to a water/oil interface is characterized by a sudden breach and an unexpectedly slow relaxation. The relaxation appears logarithmic in time, indicating that complete equilibration may take months. Surprisingly, viscous dissipation appears to play little role. Instead, the observed dynamics, which bear strong resemblance to ageing in glassy systems, agree well with a model describing activated hopping of the contact line over nanoscale surface heterogeneities. These results may provide clues to longstanding questions on colloidal interactions at an interface.

/pdf/physical-ageing-of-the-contact-line-on-colloidal-particles-3cl8fijaew.pdf

Physical ageing of the contact line on colloidal particles at liquid interfaces

A high velocity impact between a liquid droplet and a solid surface produces a splash. Classical work traced the origin of the splash to a thin sheet of fluid ejected near the impact point. Mechanisms of sheet formation have heretofore relied on initial contact of the droplet and the surface. We demonstrate that, neglecting intermolecular forces between the liquid and the solid, the liquid does not contact the solid, and instead spreads on a very thin air film. The interface of the droplet develops a high curvature and emits capillary waves.

Precursors to Splashing of Liquid Droplets on a Solid Surface

Principles of E-Cadherin Supramolecular Organization In Vivo

A high-velocity (≈1 m s ―1 ) impact between a liquid droplet (≈1 mm) and a solid surface produces a splash. Classical observations traced the origin of this splash to a thin sheet of fluid ejected near the impact point, though the fluid mechanical mechanism leading to the sheet is not known. Mechanisms of sheet formation have heretofore relied on initial contact of the droplet and the surface. In this paper, we theoretically and numerically study the events within the time scale of about 1 μs over which the coupled dynamics between the gas and the droplet becomes important. The droplet initially tries to contact the substrate by either draining gas out of a thin layer or compressing it, with the local behaviour described by a self-similar solution of the governing equations. This similarity solution is not asymptotically consistent: forces that were initially negligible become relevant and dramatically change the behaviour. Depending on the radius and impact velocity of the droplet, we show that the solution is overtaken by initially subdominant physical effects such as the surface tension of the liquid―gas interface or viscous forces in the liquid. At low impact velocities surface tension stops the droplet from impacting the surface, whereas at higher velocities viscous forces become important before surface tension. The ultimate dynamics of the interface once droplet viscosity cannot be neglected is not yet known.

Events before droplet splashing on a solid surface

A high-velocity (≈1 ms−1) impact between a liquid droplet (≈1 mm) and a solid surface produces a splash. Classical observations traced the origin of this splash to a thin sheet of fluid ejected near the impact point, though the fluid mechanical mechanism leading to the sheet is not known. Mechanisms of sheet formation have heretofore relied on initial contact of the droplet and the surface. In this paper, we theoretically and numerically study the events within the time scale of about 1 μs over which the coupled dynamics between the gas and the droplet becomes important. The droplet initially tries to contact the substrate by either draining gas out of a thin layer or compressing it, with the local behaviour described by a self-similar solution of the governing equations. This similarity solution is not asymptotically consistent: forces that were initially negligible become relevant and dramatically change the behaviour. Depending on the radius and impact velocity of the droplet, we show that the solution is overtaken by initially subdominant physical effects such as the surface tension of the liquid–gas interface or viscous forces in the liquid. At low impact velocities surface tension stops the droplet from impacting the surface, whereas at higher velocities viscous forces become important before surface tension. The ultimate dynamics of the interface once droplet viscosity cannot be neglected is not yet known.

Madhav Mani

Papers

Physical ageing of the contact line on colloidal particles at liquid interfaces

Precursors to Splashing of Liquid Droplets on a Solid Surface

Principles of E-Cadherin Supramolecular Organization In Vivo

Events before droplet splashing on a solid surface

Events before droplet splashing on a solid surface