抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

The potential for sea ice-albedo feedback to give rise to nonlinear climate change in the Arctic Ocean – defined as a nonlinear relationship between polar and global temperature change or, equivalently, a time-varying polar amplification – is explored in IPCC AR4 climate models. Five models supplying SRES A1B ensembles for the 21 st century are examined and very linear relationships are found between polar and global temperatures (indicating linear Arctic Ocean climate change), and between polar temperature and albedo (the potential source of nonlinearity). Two of the climate models have Arctic Ocean simulations that become annually sea ice-free under the stronger CO 2 increase to quadrupling forcing. Both of these runs show increases in polar amplification at polar temperatures above-5 o C and one exhibits heat budget changes that are consistent with the small ice cap instability of simple energy balance models. Both models show linear warming up to a polar temperature of-5 o C, well above the disappearance of their September ice covers at about-9 o C. Below-5 o C, surface albedo decreases smoothly as reductions move, progressively, to earlier parts of the sunlit period. Atmospheric heat transport exerts a strong cooling effect during the transition to annually ice-free conditions. Specialized experiments with atmosphere and coupled models show that the main damping mechanism for sea ice region surface temperature is reduced upward heat flux through the adjacent ice-free oceans resulting in reduced atmospheric heat transport into the region.

Geophysical fluid dynamics.

The dynamics and stability of thin liquid films have fascinated scientists over many decades: the observations of regular wave patterns in film flows down a windowpane or along guttering, the patterning of dewetting droplets, and the fingering of viscous flows down a slope are all examples that are familiar in daily life. Thin film flows occur over a wide range of length scales and are central to numerous areas of engineering, geophysics, and biophysics; these include nanofluidics and microfluidics, coating flows, intensive processing, lava flows, dynamics of continental ice sheets, tear-film rupture, and surfactant replacement therapy. These flows have attracted considerable attention in the literature, which have resulted in many significant developments in experimental, analytical, and numerical research in this area. These include advances in understanding dewetting, thermocapillary- and surfactant-driven films, falling films and films flowing over structured, compliant, and rapidly rotating substrates, and evaporating films as well as those manipulated via use of electric fields to produce nanoscale patterns. These developments are reviewed in this paper and open problems and exciting research avenues in this thriving area of fluid mechanics are also highlighted.

Dynamics and stability of thin liquid films

Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves

Materials that control ice accumulation are important to aircraft efficiency, highway and powerline maintenance, and building construction. Most current deicing systems include either physical or chemical removal of ice, both energy and resource-intensive. A more desirable approach would be to prevent ice formation rather than to fight its build-up. Much attention has been given recently to freezing of static water droplets resting on supercooled surfaces. Ice accretion, however, begins with the droplet/substrate collision followed by freezing. Here we focus on the behavior of dynamic droplets impacting supercooled nano- and microstructured surfaces. Detailed experimental analysis of the temperature-dependent droplet/surface interaction shows that highly ordered superhydrophobic materials can be designed to remain entirely ice-free down to ca. -25 to -30 °C, due to their ability to repel impacting water before ice nucleation occurs. Ice accumulated below these temperatures can be easily removed. Factors contributing to droplet retraction, pinning and freezing are addressed by combining classical nucleation theory with heat transfer and wetting dynamics, forming the foundation for the development of rationally designed ice-preventive materials. In particular, we emphasize the potential of hydrophobic polymeric coatings bearing closed-cell surface microstructures for their improved mechanical and pressure stability, amenability to facile replication and large-scale fabrication, and opportunities for greater tuning of their material and chemical properties.

https://www.motor-talk.de/forum/aktion/Attachment.html?attachmentId=694503

Design of ice-free nanostructured surfaces based on repulsion of impacting water droplets.

When a liquid drop contacts a wettable surface, the liquid spreads over the solid to minimize the total surface energy. The first moments of spreading tend to be rapid. For example, a millimeter-sized water droplet will wet an area having the same diameter as the drop within a millisecond. For perfectly wetting systems, this spreading is inertially dominated. Here we identify that even in the presence of a contact line, the initial wetting is dominated by inertia rather than viscosity. We find that the spreading radius follows a power-law scaling in time where the exponent depends on the equilibrium contact angle. We propose a model, consistent with the experimental results, in which the surface spreading is regulated by the generation of capillary waves.

/pdf/short-time-dynamics-of-partial-wetting-1tghxnbc6q.pdf

Short-Time Dynamics of Partial Wetting

A high velocity impact between a liquid droplet and a solid surface produces a splash. Classical work traced the origin of the splash to a thin sheet of fluid ejected near the impact point. Mechanisms of sheet formation have heretofore relied on initial contact of the droplet and the surface. We demonstrate that, neglecting intermolecular forces between the liquid and the solid, the liquid does not contact the solid, and instead spreads on a very thin air film. The interface of the droplet develops a high curvature and emits capillary waves.

Precursors to Splashing of Liquid Droplets on a Solid Surface

The commonly accepted description of drops impacting on a surface typically ignores the essential role of the air that is trapped between the impacting drop and the surface. Here we describe a new imaging modality that is sensitive to the behavior right at the surface. We show that a very thin film of air, only a few tens of nanometers thick, remains trapped between the falling drop and the surface as the drop spreads. The thin film of air serves to lubricate the drop enabling the fluid to skate on the air film laterally outward at surprisingly high velocities, consistent with theoretical predictions. Eventually this thin film of air breaks down as the fluid wets the surface via a spinodal-like mechanism. Our results show that the dynamics of impacting drops are much more complex than previously thought, with a rich array of unexpected phenomena that require rethinking classic paradigms.

/pdf/skating-on-a-film-of-air-drops-impacting-on-a-surface-4d1pc9nihs.pdf

Skating on a film of air: drops impacting on a surface.

A high-velocity (≈1 m s ―1 ) impact between a liquid droplet (≈1 mm) and a solid surface produces a splash. Classical observations traced the origin of this splash to a thin sheet of fluid ejected near the impact point, though the fluid mechanical mechanism leading to the sheet is not known. Mechanisms of sheet formation have heretofore relied on initial contact of the droplet and the surface. In this paper, we theoretically and numerically study the events within the time scale of about 1 μs over which the coupled dynamics between the gas and the droplet becomes important. The droplet initially tries to contact the substrate by either draining gas out of a thin layer or compressing it, with the local behaviour described by a self-similar solution of the governing equations. This similarity solution is not asymptotically consistent: forces that were initially negligible become relevant and dramatically change the behaviour. Depending on the radius and impact velocity of the droplet, we show that the solution is overtaken by initially subdominant physical effects such as the surface tension of the liquid―gas interface or viscous forces in the liquid. At low impact velocities surface tension stops the droplet from impacting the surface, whereas at higher velocities viscous forces become important before surface tension. The ultimate dynamics of the interface once droplet viscosity cannot be neglected is not yet known.

Events before droplet splashing on a solid surface

From rain storms to ink jet printing, it is ubiquitous that a high-speed liquid droplet creates a splash when it impacts on a dry solid surface. Yet, the fluid mechanical mechanism causing this splash is unknown. About fifty years ago it was discovered that corona splashes are preceded by the ejection of a thin fluid sheet very near the vicinity of the contact point. Here we present a first-principles description of the mechanism for sheet formation, the initial stages of which occur before the droplet physically contacts the surface. We predict precisely when sheet formation occurs on a smooth surface as a function of experimental parameters, along with conditions on the roughness and other parameters for the validity of the predictions. The process of sheet formation provides a semi-quantitative framework for studying the subsequent events and the influence of liquid viscosity, gas pressure and surface roughness. The conclusions derived from this framework are in quantitative agreement with previous measurements of the splash threshold as a function of impact parameters (the size and velocity of the droplet) and in qualitative agreement with the dependence on physical properties (liquid viscosity, surface tension, ambient gas pressure, etc.) Our analysis predicts an as yet unobserved series of events within micrometres of the impact point and microseconds of the splash.

Shreyas Mandre

Papers

Short-Time Dynamics of Partial Wetting

Precursors to Splashing of Liquid Droplets on a Solid Surface

Skating on a film of air: drops impacting on a surface.

Events before droplet splashing on a solid surface

The mechanism of a splash on a dry solid surface