M
Madhuri Dasari
Researcher at Georgia Institute of Technology
Publications - 11
Citations - 811
Madhuri Dasari is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Hydrogen peroxide & Prodrug. The author has an hindex of 7, co-authored 9 publications receiving 733 citations. Previous affiliations of Madhuri Dasari include Parker H. Petit Institute for Bioengineering & Bioscience & The Wallace H. Coulter Department of Biomedical Engineering.
Papers
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Journal ArticleDOI
In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles
Dongwon Lee,Sirajud D. Khaja,Juan C. Velasquez-Castano,Madhuri Dasari,Carrie Q. Sun,John A. Petros,John A. Petros,W. Robert Taylor,W. Robert Taylor,W. Robert Taylor,Niren Murthy +10 more
TL;DR: It is demonstrated that nanoparticles formulated from peroxalate esters and fluorescent dyes can image hydrogen peroxide in vivo with high specificity and sensitivity and deep-tissue-imaging capability.
Journal ArticleDOI
Photocrosslinkable chitosan based hydrogels for neural tissue engineering
Chandra M. Valmikinathan,Vivek Mukhatyar,Anjana Jain,Lohitash Karumbaiah,Madhuri Dasari,Ravi V. Bellamkonda +5 more
TL;DR: The development of a novel chitosan based photocrosslinkable hydrogel system with tunable mechanical properties and degradation rates is reported and contributes to an increasing repertoire of hydrogels designed for neural tissue engineering.
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Detection of hydrogen peroxide with chemiluminescent micelles
TL;DR: The peroxalate micelles are presented, which detect hydrogen peroxide through chemiluminescence, and have the physical/chemical properties needed for in vivo imaging applications, and are anticipated to have numerous applications, given their high sensitivity, small size, and biocompatible PEG corona.
Journal ArticleDOI
Hoechst-IR: An Imaging Agent That Detects Necrotic Tissue in Vivo by Binding Extracellular DNA
Madhuri Dasari,Sungmun Lee,Jay C. Sy,Dongin Kim,Seungjun Lee,Milton E. Brown,Michael Davis,Niren Murthy +7 more
TL;DR: Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/d-galactosamine (LPS-GalN) induced sepsis.
Journal ArticleDOI
H-gemcitabine: a new gemcitabine prodrug for treating cancer.
Madhuri Dasari,Abhinav P. Acharya,Dongin Kim,Seungjun Lee,Sungmun Lee,Jeanne M. Rhea,Ross J. Molinaro,Niren Murthy +7 more
TL;DR: It is demonstrated here that H-gem citabine has a wider therapeutic window than free gemcitabine, and still has high tumor efficacy because of its ability to target gemcitABine to E-DNA in tumors.