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W. Robert Taylor
Researcher at Emory University
Publications - 44
Citations - 7206
W. Robert Taylor is an academic researcher from Emory University. The author has contributed to research in topics: Angiotensin II & Vascular smooth muscle. The author has an hindex of 27, co-authored 44 publications receiving 6794 citations. Previous affiliations of W. Robert Taylor include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Dan Sorescu,Daiana Weiss,Bernard Lassègue,Roza E. Clempus,Katalin Szöcs,George P. Sorescu,Liisa Valppu,Mark T. Quinn,J. David Lambeth,J. David Vega,W. Robert Taylor,Kathy K. Griendling +11 more
TL;DR: Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary Atherosclerotic disease.
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Role of NADH/NADPH Oxidase–Derived H2O2 in Angiotensin II–Induced Vascular Hypertrophy
A. Maziar Zafari,Masuko Ushio-Fukai,Marjorie Akers,Qiqin Yin,Aalok Shah,David G. Harrison,W. Robert Taylor,Kathy K. Griendling +7 more
TL;DR: Data indicate that AT1 receptor-mediated production of superoxide generated by the NADH/NADPH oxidase is followed by an increase in intracellular H2O2, suggesting a specific role for these oxygen species and scavenging systems in modifying the intrACEllular redox state in vascular growth.
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p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats
Toshiki Fukui,Nobukazu Ishizaka,Sanjay Rajagopalan,Jørn Bech Laursen,Quinn Capers,W. Robert Taylor,David G. Harrison,Hector De Leon,Josiah N. Wilcox,Kathy K. Griendling +9 more
TL;DR: The findings suggest that Ang II-induced hypertension activates the NADPH/NADH oxidase system by upregulating mRNA levels of one or several components of this oxid enzyme system, including the p22phox, and that the NAD PH/NadH oxidases system is associated with the pathology of hypertension in vivo.
Journal ArticleDOI
In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles
Dongwon Lee,Sirajud D. Khaja,Juan C. Velasquez-Castano,Madhuri Dasari,Carrie Q. Sun,John A. Petros,John A. Petros,W. Robert Taylor,W. Robert Taylor,W. Robert Taylor,Niren Murthy +10 more
TL;DR: It is demonstrated that nanoparticles formulated from peroxalate esters and fluorescent dyes can image hydrogen peroxide in vivo with high specificity and sensitivity and deep-tissue-imaging capability.
Journal ArticleDOI
Nox1 overexpression potentiates angiotensin ii-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
Anna Dikalova,Roza E. Clempus,Bernard Lassègue,Guangjie Cheng,James McCoy,Sergey Dikalov,Alejandra San Martin,Alicia N. Lyle,David S. Weber,Daiana Weiss,W. Robert Taylor,Harald H.H.W. Schmidt,Gary K. Owens,J. David Lambeth,Kathy K. Griendling +14 more
TL;DR: Data indicate that smooth muscle-specific Nox1 overexpression augments the oxidative, pressor, and hypertrophic responses to Ang II, supporting the concept that medial Nox 1 participates in the development of cardiovascular pathologies.