M
Madhusudhana Gargesha
Researcher at Case Western Reserve University
Publications - 37
Citations - 1253
Madhusudhana Gargesha is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Optical coherence tomography & Mesenchymal stem cell. The author has an hindex of 16, co-authored 34 publications receiving 1090 citations. Previous affiliations of Madhusudhana Gargesha include Beta.
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Journal ArticleDOI
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser
Michael W. Jenkins,Desmond C. Adler,Madhusudhana Gargesha,Robert Huber,Florence Rothenberg,J. Belding,Michiko Watanabe,David L. Wilson,James G. Fujimoto,Andrew M. Rollins +9 more
TL;DR: This marks the first time that the preseptated embryonic avian heart has been imaged in 4D without the aid of gating and the firsttime it has been viewed in cross section during looping with extremely high temporal resolution, enabling the observation of morphological dynamics of the beating heart during systole.
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Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
Jason M. Newbern,Jian Zhong,Rasika S. Wickramasinghe,Xiaoyan Li,Yaohong Wu,Ivy S. Samuels,Natalie Cherosky,J. Colleen Karlo,Brianne O'Loughlin,Jamie Wikenheiser,Madhusudhana Gargesha,Yong Qiu Doughman,Jean Charron,David D. Ginty,Michiko Watanabe,Sulagna C. Saitta,William D. Snider,Gary E. Landreth +17 more
TL;DR: It is suggested that the craniofacial and cardiac outflow tract defects observed in patients with a distal 22q11.2 micro-deletion are explained by deficiencies in neural crest autonomous ERK2 signaling.
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Inactivated Mesenchymal Stem Cells Maintain Immunomodulatory Capacity
Franka Luk,Samantha F.H. de Witte,Sander S. Korevaar,Marieke Roemeling-van Rhijn,Marcella Franquesa,Tanja Strini,Sandra van den Engel,Madhusudhana Gargesha,Debashish Roy,Frank J. M. F. Dor,Edwin M. Horwitz,Ron W. F. de Bruin,Michiel G. H. Betjes,Carla C. Baan,Martin J. Hoogduijn +14 more
TL;DR: The results of this study demonstrate that, in particular disease models, the immunomodulatory effect of MSC does not depend on their secretome or active cross-talk with immune cells, but on recognition of M SC by monocytic cells.
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3D Cryo-Imaging: A Very High-Resolution View of the Whole Mouse
Debashish Roy,Grant J. Steyer,Madhusudhana Gargesha,Meredith E. Stone,David L. Wilson,David L. Wilson +5 more
TL;DR: A mouse, in which enhanced green fluorescent protein was expressed under gamma actin promoter in smooth muscle cells, gave clear 3D views of smooth muscle in the urogenital and gastrointestinal tracts, and cryo‐imaging could obtain 3D vasculature down to 10 μm, over very large regions of mouse brain.
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Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images
Zhao Wang,Hiroyuki Kyono,Hiram G. Bezerra,Hui Wang,Madhusudhana Gargesha,Chadi Alraies,Chenyang Xu,Joseph M. Schmitt,David L. Wilson,Marco A. Costa,Andrew M. Rollins +10 more
TL;DR: It is suggested that the proposed method can be used for automated CP analysis in OCT, thereby facilitating the understanding of coronary artery calcification in the process of atherosclerosis and helping guide complex interventional strategies in coronary arteries with superficial calcification.