Mafalda Almeida

TL;DR: It is shown that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)–PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to XistRNA expression, overturning existing models for Polycomb recruitment by Xist RNA and establishing precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context.

TL;DR: A systematic analysis of Xist-mediated allelic silencing in mouse ESC models is described and the contribution of different pathways that regulate gene silencing is defined.

TL;DR: In this paper, the authors evaluated whether ETS transcription factors frequently involved in rearrangements in prostate carcinomas (PCa), namely ERG and ETV1, regulate specific or shared target genes.

TL;DR: It is concluded that ETS transcription factors regulate specific and shared target genes and that TDRD1, FKBP10, and GRPR are promising therapeutic targets and can serve as diagnostic markers for molecular subtypes of PCa harboring specific fusion gene rearrangements.

TL;DR: GDF15, TMEFF2 and V IM promoter methylation allows for accurate identification of UTUC, in tissue and urine and VIM methylation provides relevant prognostic information, especially in high-stage disease.