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Chun-Xiao Song
Researcher at Ludwig Institute for Cancer Research
Publications - 69
Citations - 11998
Chun-Xiao Song is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 37, co-authored 66 publications receiving 10524 citations. Previous affiliations of Chun-Xiao Song include Jilin University & Peking University.
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Journal ArticleDOI
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
Yu-Fei He,Bin-Zhong Li,Zheng Li,Peng Liu,Yang Wang,Qingyu Tang,Jianping Ding,Yingying Jia,Zhangcheng Chen,Lin Li,Yan Sun,Xiuxue Li,Qing Dai,Chun-Xiao Song,Kangling Zhang,Chuan He,Guoliang Xu +16 more
TL;DR: It is demonstrated that 5mC and 5hmC in DNA are oxidized to 5-carboxylcytosine (5caC) by Tet dioxygenases in vitro and in cultured cells, suggesting that oxidation of 5m C by Tet proteins followed by TDG-mediated base excision of 5caC constitutes a pathway for active DNA demethylation.
Journal ArticleDOI
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio,Linsey Reavie,Alan Shih,Omar Abdel-Wahab,Delphine Ndiaye-Lobry,Camille Lobry,Maria E. Figueroa,Aparna Vasanthakumar,Jay P. Patel,Xinyang Zhao,Fabiana Perna,Suveg Pandey,Jozef Madzo,Chun-Xiao Song,Qing Dai,Chuan He,Sherif Ibrahim,Miloslav Beran,Jiri Zavadil,Stephen D. Nimer,Stephen D. Nimer,Ari Melnick,Lucy A. Godley,Iannis Aifantis,Ross L. Levine +24 more
TL;DR: An animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays is reported.
Journal ArticleDOI
Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
Miao Yu,Gary C. Hon,Keith E. Szulwach,Chun-Xiao Song,Liang Zhang,Audrey Kim,Xuekun Li,Qing Dai,Yin Shen,Beomseok Park,Jung Hyun Min,Peng Jin,Bing Ren,Chuan He +13 more
TL;DR: Application of Tet-assisted bisulfite sequencing to embryonic stem cells not only confirms widespread distribution of 5hmC in the mammalian genome but also reveals sequence bias and strand asymmetry at5hmC sites.
Journal ArticleDOI
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
Chun-Xiao Song,Keith E. Szulwach,Ye Fu,Qing Dai,Chengqi Yi,Xuekun Li,Yujing Li,Chih Hsin Chen,Wen Zhang,Xing Jian,Jing Wang,Li Zhang,Timothy J. Looney,Baichen Zhang,Lucy A. Godley,Leslie M. Hicks,Bruce T. Lahn,Peng Jin,Chuan He +18 more
TL;DR: This method uses the T4 bacteriophage β-glucosyltransferase to transfer an engineered glucose moiety containing an azide group onto the hydroxyl group of 5-hmC, a recently identified epigenetic modification present in substantial amounts in certain mammalian cell types.
Journal ArticleDOI
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
Keith E. Szulwach,Xuekun Li,Yujing Li,Chun-Xiao Song,Hao Wu,Qing Dai,Hasan A. Irier,Anup K. Upadhyay,Marla Gearing,Allan I. Levey,Aparna Vasanthakumar,Lucy A. Godley,Qiang Chang,Xiaodong Cheng,Chuan He,Peng Jin +15 more
TL;DR: The mapped 5-hmC genome-wide in mouse hippocampus and cerebellum at three different ages allowed us to assess its stability and dynamic regulation during postnatal neurodevelopment through adulthood, and found developmentally programmed acquisition of 5-HMC in neuronal cells.