M
Magali Saint-Geniez
Researcher at Harvard University
Publications - 67
Citations - 5320
Magali Saint-Geniez is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor A. The author has an hindex of 29, co-authored 62 publications receiving 4604 citations. Previous affiliations of Magali Saint-Geniez include Boston University & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors.
Magali Saint-Geniez,Arindel S.R. Maharaj,Tony E. Walshe,Budd A. Tucker,Eiichi Sekiyama,Tomoki Kurihara,Diane C. Darland,Michael J. Young,Patricia A. D'Amore +8 more
TL;DR: Results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution.
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An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
TL;DR: Increased photoreceptor apoptosis in aged VEGF188/188 mice led to a decline in visual acuity as detected by electroretinogram (ERG), and changes are reminiscent of geographic atrophy (GA) and point to a role for RPE-derived V EGF in the maintenance of the choriocapillaris.
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PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
Mei Tran,Denise Tam,Amit Bardia,Manoj Bhasin,Glenn C. Rowe,Ajay Kher,Zsuzsanna K. Zsengellér,M. Reza Akhavan-Sharif,Eliyahu V. Khankin,Magali Saint-Geniez,Sascha David,Deborah Burstein,S. Ananth Karumanchi,Isaac E. Stillman,Zoltan Arany,Samir M. Parikh +15 more
TL;DR: It is shown that endotoxemia reduces oxygen delivery to the kidney, without changing tissue oxygen levels, suggesting reduced oxygen consumption by the kidney cells, and that PGC-1α induction may be necessary for recovery from this disorder.
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Development and pathology of the hyaloid, choroidal and retinal vasculature
TL;DR: The characterization of the molecules and cell-cell interactions involved in the formation, stabilization and regression of new vessels has led to the identification of potential control points for therapeutic intervention.
Journal ArticleDOI
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival.
Diane C. Darland,Lauren J. Massingham,Sandra R. Smith,E Piek,Magali Saint-Geniez,Patricia A. D'Amore +5 more
TL;DR: Observations indicate that differentiated pericytes produce VEGF that may act in a juxtacrine/paracrine manner as a survival and/or stabilizing factor for EC in microvessels.