S
S. Ananth Karumanchi
Researcher at Cedars-Sinai Medical Center
Publications - 392
Citations - 46701
S. Ananth Karumanchi is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Preeclampsia & Pregnancy. The author has an hindex of 92, co-authored 365 publications receiving 40065 citations. Previous affiliations of S. Ananth Karumanchi include University of Mississippi Medical Center & Beth Israel Deaconess Medical Center.
Papers
More filters
Journal ArticleDOI
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Sharon Maynard,Jiang Yong Min,Jaime R. Merchan,Kee-Hak Lim,Jianyi Li,Susanta Mondal,Towia A. Libermann,James P. Morgan,Frank W. Sellke,Isaac E. Stillman,Franklin H. Epstein,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: It is confirmed that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt 1 that fall after delivery, and observations suggest that excess circulating sFelt1 contributes to the pathogenesis of preeClampsia.
Journal ArticleDOI
Hypertension in pregnancy: Executive summary
James M. Roberts,Phyllis August,George Bakris,John R. Barton,Ira M. Bernstein,Maurice L. Druzin,Robert R. Gaiser,Joey P. Granger,Arun Jeyabalan,Donna D. Johnson,S. Ananth Karumanchi,Marshall D. Lindheimer,Michelle Y. Owens,Geroge R. Saade,Bahaeddine M Sibai,Catherine Y. Spong,Eleni Tsigas,Gerald E. Joseph,Nancy O'Reilly,Alyssa Politzer,Sarah Son,Karina Ngaiza +21 more
Journal ArticleDOI
Circulating Angiogenic Factors and the Risk of Preeclampsia
Richard J. Levine,Sharon Maynard,Cong Qian,Kee-Hak Lim,Lucinda England,Kai F. Yu,Enrique F. Schisterman,Ravi Thadhani,Benjamin P. Sachs,Franklin H. Epstein,Bahaeddine M Sibai,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: Alterations in the levels of sFlt-1 and free PlGF were greater in women with an earlier onset of preeclampsia and in women in whom preeClampsia was associated with a small-for-gestational-age infant.
Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal ArticleDOI
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
Richard J. Levine,Chun Lam,Cong Qian,Kai F. Yu,Sharon Maynard,Benjamin P. Sachs,Baha M. Sibai,Franklin H. Epstein,Roberto Romero,Roberto Romero,Ravi Thadhani,S. Ananth Karumanchi +11 more
TL;DR: Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia, which was greatest among women in the highest quartile of the control distributions for both biomarkers but not for either biomarker alone.