M
Magnus Hultdin
Researcher at Umeå University
Publications - 43
Citations - 1985
Magnus Hultdin is an academic researcher from Umeå University. The author has contributed to research in topics: Telomere & DNA methylation. The author has an hindex of 16, co-authored 40 publications receiving 1692 citations. Previous affiliations of Magnus Hultdin include Linköping University & Uppsala University.
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Journal ArticleDOI
Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia
Gerard Tobin,Ulf Thunberg,A. Johnson,Ingrid Thörn,Ola Söderberg,Magnus Hultdin,Johan Botling,Gunilla Enblad,Jan Sällström,Christer Sundström,Göran Roos,Richard Rosenquist +11 more
TL;DR: Interestingly, the subset of mutated cases using the V(H)3-21 gene displayed distinctive genotypic/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of lambda light chains, and showed significantly shorter survival than other mutated cases.
Journal ArticleDOI
Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients
Karin Forsberg,P. Andreas Jonsson,Peter M. Andersen,Daniel Bergemalm,Karin S. Graffmo,Magnus Hultdin,Johan Jacobsson,Roland Rosquist,Stefan L. Marklund,Thomas Brännström +9 more
TL;DR: Granular inclusions were found in spinal motoneurons of sporadic and familial ALS patients studied and they were the major type of inclusion detected in ALS patients homozygous for the wild type-like D90A mutation, suggesting that SOD1 may be involved in ALS pathogenesis in patients lacking mutations in the enzyme.
Journal ArticleDOI
Telomere analysis by fluorescence in situ hybridization and flow cytometry
Magnus Hultdin,Elisabeth Grönlund,Karl-Fredrik Norrback,E Eriksson-Lindström,T Just,Göran Roos +5 more
TL;DR: With the Q-FISHFCM method the fluorescence signal could be determined in different cell cycle phases, indicating that in human cells the vast majority of telomeric DNA is replicated early in S phase.
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Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status
Pawel Grabowski,Pawel Grabowski,Pawel Grabowski,Magnus Hultdin,Magnus Hultdin,Magnus Hultdin,Karin H. Karlsson,Karin H. Karlsson,Karin H. Karlsson,Gerard Tobin,Gerard Tobin,Gerard Tobin,Anna Åleskog,Anna Åleskog,Anna Åleskog,Ulf Thunberg,Ulf Thunberg,Ulf Thunberg,Anna Laurell,Anna Laurell,Anna Laurell,Christer Sundström,Christer Sundström,Christer Sundström,Richard Rosenquist,Richard Rosenquist,Richard Rosenquist,Göran Roos,Göran Roos,Göran Roos +29 more
TL;DR: By combining V(H) mutation status and telomere length, an improved subclassification of CLL was achieved identifying previously unrecognized patient groups with different outcomes.
Journal ArticleDOI
Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia
Ulf Thunberg,Gerard Tobin,A. Johnson,Ola Söderberg,Leonid Padyukov,Magnus Hultdin,Lars Klareskog,Gunilla Enblad,Christer Sundström,Göran Roos,Richard Rosenquist +10 more
TL;DR: Overall survival was significantly longer for patients with CLL heterozygous for the 1513C allele than those with the1513A/A genotype, and the P2X7 receptor polymorphism could affect clinical outcome in CLL, especially in patients with mutated V(H) genes.