S
Stefan L. Marklund
Researcher at Umeå University
Publications - 281
Citations - 31288
Stefan L. Marklund is an academic researcher from Umeå University. The author has contributed to research in topics: Superoxide dismutase & SOD1. The author has an hindex of 77, co-authored 276 publications receiving 29319 citations. Previous affiliations of Stefan L. Marklund include Kumamoto University & Swedish University of Agricultural Sciences.
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Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts,Erik Storkebaum,Masafumi Morimoto,Jurgen Del-Favero,Frederik Desmet,Stefan L. Marklund,Sabine Wyns,Vincent Thijs,Jörgen Andersson,Ingrid van Marion,Ammar Al-Chalabi,Stéphanie Bornes,Rhiannon Musson,Valerie K. Hansen,Lars Beckman,Rolf Adolfsson,Hardev Pall,Hervé Prats,Severine Vermeire,Paul Rutgeerts,Shigehiro Katayama,Takuya Awata,Nigel Leigh,Loïc Lang-Lazdunski,Mieke Dewerchin,Christopher Shaw,Lieve Moons,Robert Vlietinck,Robert Vlietinck,Karen E. Morrison,Wim Robberecht,Christine Van Broeckhoven,Desire Collen,Peter M. Andersen,Peter Carmeliet +34 more
TL;DR: It is indicated that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice.
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Human copper-containing superoxide dismutase of high molecular weight
TL;DR: A superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1), distinct from previously known superoxide Dismutases, has been isolated from human lung tissue and has hydrophobic properties.
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Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria
Jian Liu,Concepción Lillo,P. Andreas Jonsson,Christine Vande Velde,Christopher M. Ward,Timothy M. Miller,Jamuna R. Subramaniam,Jeffery D. Rothstein,Stefan L. Marklund,Peter M. Andersen,Thomas Brännström,Ole Gredal,Philip C. Wong,David S. Williams,Don W. Cleveland +14 more
TL;DR: Findings implicate damage from action of spinal cord-specific factors that recruit mutant SOD1 to spinal mitochondria as the basis for their selective toxicity in ALS.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.