M
Maike Seifert
Researcher at Karolinska Institutet
Publications - 12
Citations - 266
Maike Seifert is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 6, co-authored 11 publications receiving 139 citations. Previous affiliations of Maike Seifert include Science for Life Laboratory.
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Journal ArticleDOI
Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
Ahmed Ibrahim,Ahmed Ibrahim,Luisa W. Hugerth,Linnea Hases,Linnea Hases,Ashish Saxena,Maike Seifert,Quentin Thomas,Jan-Åke Gustafsson,Lars Engstrand,Cecilia Williams,Cecilia Williams +11 more
TL;DR: It is demonstrated that colitis‐induced CRC reduced the gut microbiota diversity and that loss of ERβ enhanced this process, and the data support that intestinal ERβ contributes to a more favorable microbiome that could attenuate CRC development.
Journal ArticleDOI
Effects of sampling strategy and DNA extraction on human skin microbiome investigations.
Rie Dybboe Bjerre,Luisa W. Hugerth,Fredrik Boulund,Maike Seifert,Jeanne D. Johansen,Lars Engstrand +5 more
TL;DR: Analysis of sampling technique and DNA extraction data indicate that a reduction of human DNA from 90% to 57% is feasible without lowering the success of 16S rRNA library preparation and without introducing taxonomic bias.
Journal ArticleDOI
The vaginal microbiome amplifies sex hormone-associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption.
Frideborg Bradley,Kenzie Birse,Kenzie Birse,Klara Hasselrot,Laura Noël-Romas,Laura Noël-Romas,Andrea Introini,Hugo Wefer,Hugo Wefer,Maike Seifert,Maike Seifert,Lars Engstrand,Lars Engstrand,Annelie Tjernlund,Kristina Broliden,Adam Burgener,Adam Burgener,Adam Burgener +17 more
TL;DR: The cervicovaginal proteome, inflammation, and microbiome community structure and function during the menstrual cycle is characterized and its collective impact on vaginal inflammation remains unclear.
Posted ContentDOI
A comprehensive automated pipeline for human microbiome sampling, 16S rRNA gene sequencing and bioinformatics processing
Luisa W. Hugerth,Maike Seifert,Alexandra A. L. Pennhag,Juan Du,Marica Hamsten,Ina Schuppe-Koistinen,Lars Engstrand +6 more
TL;DR: A flexible automated approach to process intestinal biopsies, fecal samples and vaginal swabs from sample collection to OTU table is described, and a set of guidelines and best practices for each of these steps are presented.
Journal ArticleDOI
Bacteriophages Synergize with the Gut Microbial Community To Combat Salmonella
Yue O. O. Hu,Yue O. O. Hu,Luisa W. Hugerth,Luisa W. Hugerth,C. Bengtsson,Arlisa Alisjahbana,Maike Seifert,Maike Seifert,Anaga Kamal,Anaga Kamal,Åsa Sjöling,Tore Midtvedt,Elisabeth Norin,Juan Du,Lars Engstrand,Lars Engstrand +15 more
TL;DR: A human gut microbiota model shows that bacteriophages (phages) are able to substantially decrease pathogenic Salmonella without perturbing the microbiota, demonstrating that phage treatment preserves the healthy gut microbiota and offers a noninvasive alternative to antibiotic treatment.