M
Maikel P. Peppelenbosch
Researcher at Erasmus University Rotterdam
Publications - 610
Citations - 25498
Maikel P. Peppelenbosch is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Signal transduction & Cancer. The author has an hindex of 74, co-authored 565 publications receiving 21791 citations. Previous affiliations of Maikel P. Peppelenbosch include University of Amsterdam & University Medical Center Groningen.
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Journal ArticleDOI
Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action
TL;DR: The action and function of six ankyrin repeat domain-containing Asb proteins in physiology and pathophysiology are reviewed and it is become clear that regulation of canonical Notch signaling and also mitochondrial function are important effectors.
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Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention.
TL;DR: The deregulated kinase activities identified herein, which include the mTOR (mammalian target of rapamycin)/p70S6K and ERK1/2 (extracellular signal-regulated kinases 1 and 2) pathways, are potential novel molecular targets in this lethal disease.
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Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling
Alessandra V. de S. Faria,Alessandra V. de S. Faria,Adamu Ishaku Akyala,Adamu Ishaku Akyala,Kaushal Parikh,Lois W. Brüggemann,C. Arnold Spek,Wanlu Cao,Marco J. Bruno,Maarten F. Bijlsma,Gwenny M. Fuhler,Maikel P. Peppelenbosch,Maikel P. Peppelenbosch +12 more
TL;DR: The observation that Patched-dependent, Smoothened-independent, noncanonical Hedgehog signaling increases Wnt/Notch signaling provides a possible explanation for the failure of Smootened antagonists in combating Hedgehog-dependent but Smootshened inhibitor–resistant cancer.
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Multipotent mesenchymal stromal cells in liver cancer: implications for tumor biology and therapy.
Pratika Y. Hernanda,Alexander Pedroza-Gonzalez,Dave Sprengers,Maikel P. Peppelenbosch,Qiuwei Pan +4 more
TL;DR: Call for caution using MSCs to treat liver cancer or even premalignant liver diseases, before conclusive evidence for safety and efficacy having been obtained, as mechanistic insight regarding this observed discrepancy in different experimental settings of liver cancer is dissected.
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TF:FVIIa‐specific activation of CREB upregulates proapoptotic proteins via protease‐activated receptor‐2
Henri H. Versteeg,Henri H. Versteeg,Keren Borensztajn,Marjolein Kerver,Wolfram Ruf,Pieter H. Reitsma,Pieter H. Reitsma,C. A. Spek,Maikel P. Peppelenbosch,Maikel P. Peppelenbosch +9 more
TL;DR: In this article, the effect of TF and Factor VIIa on cell survival and expression of apoptosis-associated proteins was monitored using BHK(TF), HaCaT and human umbilical vein endothelial cells (HUVEC).