M
Maisa Yoshimoto
Researcher at Queen's University
Publications - 58
Citations - 3277
Maisa Yoshimoto is an academic researcher from Queen's University. The author has contributed to research in topics: Fluorescence in situ hybridization & PTEN. The author has an hindex of 29, co-authored 58 publications receiving 3085 citations. Previous affiliations of Maisa Yoshimoto include Kingston General Hospital & Ontario Institute for Cancer Research.
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Journal ArticleDOI
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
Maisa Yoshimoto,Isabela Werneck da Cunha,Renata A. Coudry,Felipe Paiva Fonseca,Cesar Torres,Fernando Augusto Soares,Jeremy A. Squire,Jeremy A. Squire +7 more
TL;DR: PTEN loss at the time of prostatectomy correlated with clinical parameters of more advanced disease, such as extraprostatic extension and seminal vesicle invasion, and indicates that haploinsufficiency or PTEN genomic loss is an indicator of moreAdvanced disease at surgery, and is predictive of a shorter time to biochemical recurrence of disease.
Journal ArticleDOI
Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
Maisa Yoshimoto,Anthony M. Joshua,Isabela Werneck da Cunha,Renata A. Coudry,Francisco Paulo da Fonseca,Olga Ludkovski,Maria Zielenska,Fernando Augusto Soares,Jeremy A. Squire,Jeremy A. Squire +9 more
TL;DR: A retrospective analysis of 125 prostate cancers with known clinical outcome using interphase fluorescence in situ hybridization and multivariate analysis indicate that TMPRSS2:ERG fusion and PTEN loss together are a predictor of earlier biochemical recurrence of disease.
Journal ArticleDOI
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.
Kanishka Sircar,Maisa Yoshimoto,Federico A. Monzon,Federico A. Monzon,Ismaël Hervé Koumakpayi,Ruth L. Katz,Abha Khanna,Karla Alvarez,Karla Alvarez,Guanyong Chen,Andrew Darnel,Armen Aprikian,Fred Saad,Tarek A. Bismar,Jeremy A. Squire +14 more
TL;DR: PTEN haploinsufficiency is common in hormone‐sensitive prostate cancer, though the incidence of genomic deletion and its downstream effects have not been elucidated in clinical samples of hormone refractory prostate cancer (HRPC).
Journal ArticleDOI
Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement.
Maisa Yoshimoto,Anthony M. Joshua,Anthony M. Joshua,Susan Chilton-MacNeill,Jane Bayani,Shamini Selvarajah,Shamini Selvarajah,Andrew Evans,Maria Zielenska,Jeremy A. Squire +9 more
TL;DR: Three-color fluorescence in situ hybridization confirms that TMPRSS2/ERG fusion may be accompanied by a small hemizygous sequence deletion on chromosome 21 between ERG and TMPR SS2 genes.
Journal ArticleDOI
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias.
Maisa Yoshimoto,Jean-Claude Cutz,Paulo A. S. Nuin,Anthony M. Joshua,Anthony M. Joshua,Jane Bayani,Andrew Evans,Andrew Evans,Maria Zielenska,Jeremy A. Squire,Jeremy A. Squire +10 more
TL;DR: The high frequency of PTEN deletion observed in CaP versus precursor lesions implicates a pivotal role for PTEN haploinsufficiency in the transition from preneoplastic PIN to CaP and draws attention to the usefulness of this relatively simple FISH assay for future applications in clinical laboratories.