M
Makoto Sonobe
Researcher at Kyoto University
Publications - 169
Citations - 4120
Makoto Sonobe is an academic researcher from Kyoto University. The author has contributed to research in topics: Lung cancer & Adenocarcinoma. The author has an hindex of 31, co-authored 158 publications receiving 3480 citations.
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Journal ArticleDOI
Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients.
Akihiko Yoshizawa,Shinji Sumiyoshi,Makoto Sonobe,Masashi Kobayashi,Masakazu Fujimoto,Fumi Kawakami,Tatsuaki Tsuruyama,William D. Travis,Hiroshi Date,Hironori Haga +9 more
TL;DR: The IASLC/ATS/ERS classification identified prognostic histologic subtypes of lung adenocarcinomas among Japanese patients and revealed that the new classification was an independent predictor of disease-free survival.
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Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4–ALK Fusion Gene
Tsuyoshi Takahashi,Makoto Sonobe,Masashi Kobayashi,Akihiko Yoshizawa,Toshi Menju,Ei Nakayama,Nobuya Mino,Shotaro Iwakiri,Kiyoshi Sato,Ryo Miyahara,Kenichi Okubo,Toshiaki Manabe,Hiroshi Date +12 more
TL;DR: EML4–ALK fusion genes were observed predominantly in adenocarcinomas, in female or nonsmoking populations, and were mutually exclusive with mutations in the EGFR, KRAS, and ERBB2 genes.
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Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma
TL;DR: Adenocarcinomas with EGFR mutation had a distinctive clinico-pathological feature unrelated to smoking, suggesting that Epidermal growth factor receptor mutations may play a key role in the development of smoking-independent adenocARCinoma.
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UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
Yoko Goto,Lihua Zeng,Chan Joo Yeom,Yuxi Zhu,Akiyo Morinibu,Kazumi Shinomiya,Minoru Kobayashi,Kiichi Hirota,Satoshi Itasaka,Michio Yoshimura,Keiji Tanimoto,Masae Torii,Terumasa Sowa,Toshi Menju,Makoto Sonobe,Hideaki Kakeya,Masakazu Toi,Hiroshi Date,Ester M. Hammond,Masahiro Hiraoka,Hiroshi Harada +20 more
TL;DR: It is shown that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of Hif-1α, the regulatory subunit of HIF-1, and consequently promotes metastasis.
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Use of virtual assisted lung mapping (VAL-MAP), a bronchoscopic multispot dye-marking technique using virtual images, for precise navigation of thoracoscopic sublobar lung resection.
Masaaki Sato,Mitsugu Omasa,Fengshi Chen,Toshihiko Sato,Makoto Sonobe,Toru Bando,Hiroshi Date +6 more
TL;DR: 3-dimensional virtual images were used and multiple markings made on the lung surface to provide "geometric" information, and this technique "virtual assisted lung mapping" (VAL-MAP) was safely conducted with satisfactory outcomes in early experience.