M
Mala Chakraborty
Researcher at National Institutes of Health
Publications - 38
Citations - 3845
Mala Chakraborty is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antigen & Carcinoembryonic antigen. The author has an hindex of 23, co-authored 34 publications receiving 3432 citations. Previous affiliations of Mala Chakraborty include Markey Cancer Center.
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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric Reits,James W. Hodge,Carla A. Herberts,Tom A.M. Groothuis,Mala Chakraborty,Elizabeth K. Wansley,Kevin Camphausen,Rosalie M. Luiten,Arnold H. de Ru,Joost Neijssen,Alexander Griekspoor,Elly Mesman,Frank A. W. Verreck,Hergen Spits,Jeffrey Schlom,Peter A. van Veelen,Jacques Neefjes +16 more
TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.
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Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
Mala Chakraborty,Scott I. Abrams,Kevin Camphausen,Kebin Liu,Tamalee Scott,C. Norman Coleman,James W. Hodge +6 more
TL;DR: Results showed for the first time that regulation of the Fas pathway in tumor cells by irradiation plays an important role in their sensitization to Ag-specific CTL; and a combination regimen of tumor-targeted irradiation and CTL promotes more effective antitumor responses in vivo, which may have implications for the combination of immunotherapy and radiation therapy.
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External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.
Mala Chakraborty,Scott I. Abrams,C. Norman Coleman,Kevin Camphausen,Jeffrey Schlom,James W. Hodge +5 more
TL;DR: A new paradigm for the use of local tumor irradiation in combination with active specific vaccine therapy to elicit durable antitumor responses of established tumors is demonstrated.
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Immune Response to the Carcinoembryonic Antigen in Patients Treated with an Anti-Idiotype Antibody Vaccine
Kenneth A. Foon,Mala Chakraborty,William J. John,Amanda Sherratt,Heinz Kohler,Malaya Bhattacharya-Chatterjee +5 more
TL;DR: This is the first report demonstrating that a vaccine therapy is capable of breaking "immune tolerance" to CEA in patients with CEA positive tumors.
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Clinical and Immune Responses in Resected Colon Cancer Patients Treated With Anti-Idiotype Monoclonal Antibody Vaccine That Mimics the Carcinoembryonic Antigen
Kenneth A. Foon,William J. John,Mala Chakraborty,Ruma Das,April Teitelbaum,Juanita Garrison,Oscar Kashala,Sunil K. Chatterjee,Malaya Bhattacharya-Chatterjee +8 more
TL;DR: CeaVac consistently generated a potent anti-CEA humoral and cellular immune response in all 32 patients entered onto this trial, and these data warrant a phase III trial for patients with resected colon cancer.