P
Peter A. van Veelen
Researcher at Leiden University Medical Center
Publications - 208
Citations - 12493
Peter A. van Veelen is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 54, co-authored 172 publications receiving 10822 citations. Previous affiliations of Peter A. van Veelen include Leiden University & Loyola University Medical Center.
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Journal ArticleDOI
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric Reits,James W. Hodge,Carla A. Herberts,Tom A.M. Groothuis,Mala Chakraborty,Elizabeth K. Wansley,Kevin Camphausen,Rosalie M. Luiten,Arnold H. de Ru,Joost Neijssen,Alexander Griekspoor,Elly Mesman,Frank A. W. Verreck,Hergen Spits,Jeffrey Schlom,Peter A. van Veelen,Jacques Neefjes +16 more
TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.
Journal ArticleDOI
Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes
Teun W. J. M. van Herpen,Svetlana V. Goryunova,Svetlana V. Goryunova,Johanna van der Schoot,Makedonka Mitreva,Makedonka Mitreva,Elma M. J. Salentijn,Oscar Vorst,M.F. Schenk,Peter A. van Veelen,Frits Koning,Loek J M van Soest,Ben Vosman,Dirk Bosch,Rob J. Hamer,Luud J.W.J. Gilissen,Marinus J. M. Smulders +16 more
TL;DR: The analysis shows that α-gliadin sequences from the three genomes of bread wheat form distinct groups, indicating that the three genome contribute differently to epitope content.
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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
Jing Shi,Rachel Knevel,Parawee Suwannalai,Michael P M van der Linden,George M.C. Janssen,Peter A. van Veelen,Nivine E. W. Levarht,Annette H M van der Helm-van Mil,Anthony Cerami,Tom W J Huizinga,René E. M. Toes,Leendert A. Trouw +11 more
TL;DR: Data show the presence of a unique autoantibody system recognizing carbamylated, but not citrullinated, protein antigens in the sera of rheumatoid arthritis patients, indicating that anti-CarP antibodies are a unique and relevant serological marker for ACPA-negative RA.
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The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides
Willemijn Vader,Y. Kooy,Peter A. van Veelen,Arnoud H. de Ru,Diana Harris,Willemien E. Benckhuijsen,Salvador Peña,Luisa Mearin,Jan W. Drijfhout,Frits Koning +9 more
TL;DR: The diversity of the GLU-specific T-cell response is far greater than was previously appreciated, and the observation that T- cell responses to 3 of the novel peptides are independent of deamidation indicates thatT-cell responses can be initiated toward native GLU peptides.
Journal ArticleDOI
Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease
L. Willemijn Vader,Arnoud H. de Ru,Yvonne van der Wal,Y. Kooy,Willemien E. Benckhuijsen,M. Luisa Mearin,Jan W. Drijfhout,Peter A. van Veelen,Frits Koning +8 more
TL;DR: Evidence is provided that the spacing between glutamine and proline, the second most abundant amino acid in gluten, plays an essential role in the specificity of deamidation.