Carla A. Herberts

TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.

TL;DR: It is shown that peptides with a relative molecular mass of up to ∼1,800 diffuse intercellularly through gap junctions unless a three-dimensional structure is imposed, and gap-junction-mediated peptide transfer causes cytotoxic T-cell recognition of adjacent, innocent bystander cells as well as activated monocytes.

TL;DR: It is shown that intracellular aminopeptidases degrade peptides within seconds, almost irrespectively of amino acid sequence, and three distinct proteolytic activities during antigen processing in vivo are defined.

TL;DR: This work introduces the players in the antigen processing and presentation cascade and describes their specificity and allelic variation, and highlights MHC class I alleles, which are not only different in sequence but also use different aspects of the antigen presentation pathway to their advantage.

TL;DR: It is suggested that HLA-B27 can present peptides from Ags present in fewer copies than required for successful peptide generation for other MHC class I molecules.