M
Malcolm F. G. Stevens
Researcher at University of Nottingham
Publications - 316
Citations - 13044
Malcolm F. G. Stevens is an academic researcher from University of Nottingham. The author has contributed to research in topics: Temozolomide & Benzothiazole. The author has an hindex of 57, co-authored 315 publications receiving 12291 citations. Previous affiliations of Malcolm F. G. Stevens include Keele University & Hauptman-Woodward Medical Research Institute.
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Journal ArticleDOI
Antitumour polycyclic acridines. Part 5.1 Synthesis of 7H-pyrido[4,3,2-kl]acridines with exploitable functionality in the pyridine ring
TL;DR: In this article, a series of new 9-(1,2,3-triazol-1-yl)acridines were synthesised by base catalysed cyclisation reaction of 9-azidoacridine 5 with either 1,3dicarbonyl compounds or activated acetonitriles.
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Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.
Thomas P. Garner,Huw E. L. Williams,Katarzyna I. Gluszyk,Stephen J. Roe,Neil J. Oldham,Malcolm F. G. Stevens,John E. Moses,Mark S. Searle +7 more
TL;DR: It is demonstrated that two different small molecule architectures result in significant differences in selectivity for parallel and anti-parallel quadruplex structures that may guide quadruplex targeted drug-design.
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The regiospecific synthesis of 5- and 7-monosubstituted and 5,6-disubstituted 2-arylbenzothiazoles†
TL;DR: In this article, the synthesis of 2-arylbenzothiazoles bearing both electron-withdrawing (-NO 2 ) and electron-donating (-NH 2 ) substituents on the aryl ring is described.
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Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes.
TL;DR: Activity in MDA MB 468 cells correlated with the ability to induce apoptosis following drug treatment by the most potent agents in the series, e.g., 5dy and 5jy, an observation further reinforced by AnnexinV-FITC analysis and fluorescence microscopy.
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From Triazines and Triazenes to Temozolomide
TL;DR: The discovery of temozolomide is a story of a symbiotic relationship between two cultures; on the one hand the laboratory sciences of chemistry and pharmacology and on the other the clinical sciences which impose the ultimate test of efficacy does the drug actually work in patients, or not.