M
Malcolm F. G. Stevens
Researcher at University of Nottingham
Publications - 316
Citations - 13044
Malcolm F. G. Stevens is an academic researcher from University of Nottingham. The author has contributed to research in topics: Temozolomide & Benzothiazole. The author has an hindex of 57, co-authored 315 publications receiving 12291 citations. Previous affiliations of Malcolm F. G. Stevens include Keele University & Hauptman-Woodward Medical Research Institute.
Papers
More filters
Journal ArticleDOI
Semisynthesis and in vitro anticancer activities of andrographolide analogues.
Srinivasa Rao Jada,Genevieve Suseno Subur,Charlie Matthews,Ahmad Sazali Hamzah,Nordin Haji Lajis,Mohammad Said Saad,Malcolm F. G. Stevens,Johnson Stanslas +7 more
TL;DR: The anticancer activities of these new class of compounds were not similar to that of standard anticancer agents, suggesting novel mechanism(s) of action.
Journal ArticleDOI
Antitumor Benzothiazoles. 7. Synthesis of 2-(4-Acylaminophenyl)benzothiazoles and Investigations into the Role of Acetylation in the Antitumor Activities of the Parent Amines
Mei-Sze Chua,Dong-Fang Shi,Samantha Wrigley,Tracey D. Bradshaw,Ian Hutchinson,P. Nicholas Shaw,David A. Barrett,and Lesley A. Stanley,Malcolm F. G. Stevens +8 more
TL;DR: In vitro studies confirm N-acetylation and oxidation as the main metabolic transformations of 2-(4-aminophenyl)benzothiazoles, with the predominant process being dictated by the nature of the 3'-substituent.
Journal ArticleDOI
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
A. S. Clark,B. Deans,Malcolm F. G. Stevens,M. J. Tisdale,Richard T. Wheelhouse,Brian J. Denny,John A. Hartley +6 more
TL;DR: No experimental evidence has been found to support the hypothesis that such regions are involved in catalyzing the ring opening of the imidazotetrazinone prodrugs to their active forms, and these compounds have no inhibitory properties against human GM892A or Raji cell lines in vitro.
Journal ArticleDOI
Antitumor Polycyclic Acridines. 8.1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts
Robert A. Heald,Chetna Modi,Jenny C. Cookson,Ian Hutchinson,Charles A. Laughton,Sharon Gowan,Lloyd R. Kelland,Malcolm F. G. Stevens +7 more
TL;DR: 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (12d) is soluble in water, stable in the pH range of 5-9, efficiently transported into tumor cells, and is currently the lead structure for further elaboration in this new class of telomerase inhibitor.
Journal ArticleDOI
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
C-O Leong,Margaret Gaskell,Elizabeth A. Martin,Robert T. Heydon,Peter B. Farmer,Mike C. Bibby,Patricia A. Cooper,John A. Double,Tracey D. Bradshaw,Malcolm F. G. Stevens +9 more
TL;DR: In vivo, Phortress-derived DNA adduct generation distinguished sensitive MCF-7 tumours from inherently resistant MDA-MB-435 xenografts implanted in opposite flanks of the same mouse, suggesting 1A1-dependent production of a reactive electrophilic species.