M
Malcolm F. G. Stevens
Researcher at University of Nottingham
Publications - 316
Citations - 13044
Malcolm F. G. Stevens is an academic researcher from University of Nottingham. The author has contributed to research in topics: Temozolomide & Benzothiazole. The author has an hindex of 57, co-authored 315 publications receiving 12291 citations. Previous affiliations of Malcolm F. G. Stevens include Keele University & Hauptman-Woodward Medical Research Institute.
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Journal ArticleDOI
Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
Angela Maria Rizzo,Sara Iachettini,Pasquale Zizza,Chiara Cingolani,Manuela Porru,Simona Artuso,Malcolm F. G. Stevens,Marc G. Hummersone,Annamaria Biroccio,Erica Salvati,Carlo Leonetti +10 more
TL;DR: A novel G4-stabilizing molecule, compound 8, is identified, being characterized by reduced off-target effects and potent telomere on-target properties compared to the prototypic compound 1.
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2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the aryl hydrocarbon receptor.
TL;DR: Evaluation of the anti-proliferative activity of benzothiazoles showed that the ability to agonise the AhR correlated with growth inhibition both in H4IIEC3 cells for a variety of benzothsiazoles, and between H4 IIEC3 and MCF-7 cells for 5F 203, suggesting an important role of agonism of the Ahr in the anti, proliferatives of Benzothiazole.
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Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.
Janine König,Susan Wyllie,Geoffrey Wells,Malcolm F. G. Stevens,Paul G. Wyatt,Alan H. Fairlamb +5 more
TL;DR: The quinol pharmacophore represents a novel lead structure for the development of a new drug against African sleeping sickness and shows a good correlation with growth inhibition of Trypanosoma brucei.
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Antitumour Benzothiazoles. Part 15: The Synthesis and Physico-Chemical Properties of 2-(4-Aminophenyl)benzothiazole Sulfamate Salt Derivatives
TL;DR: The sulfamate salt derivatives of the potent and selective 2-(4-aminophenyl)benzothiazole antitumour agents were found to be markedly less active than their parent amines against sensitive human tumour cell lines in vitro.
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Structural Studies on Bioactive Compounds. Part 38.1 Reactions of 5-Aminoimidazole-4-Carboxamide: Synthesis of Imidazo[1,5-a]Quinazoline-3-Carboxamides†:
TL;DR: In this article, the potassium salt of imidazo[1,5a]quinazoline-3-carboxylic acid undergoes deuterium exchange in D 2 O at the 1 position.