M
Malcolm F. G. Stevens
Researcher at University of Nottingham
Publications - 316
Citations - 13044
Malcolm F. G. Stevens is an academic researcher from University of Nottingham. The author has contributed to research in topics: Temozolomide & Benzothiazole. The author has an hindex of 57, co-authored 315 publications receiving 12291 citations. Previous affiliations of Malcolm F. G. Stevens include Keele University & Hauptman-Woodward Medical Research Institute.
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Journal ArticleDOI
Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.
N M Bleehen,Edward S. Newlands,Siow Ming Lee,Nick Thatcher,Peter Selby,Alan Hilary Calvert,Gordon J. S. Rustin,M. H. Brampton,Malcolm F. G. Stevens +8 more
TL;DR: Temozolomide in the schedule used has as good activity in chemotherapy-naive metastatic melanoma as the other most active agents currently in use.
Journal ArticleDOI
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
S.M. O'Reilly,Edward S. Newlands,M. H. Brampton,M.G. Glaser,J.M. Rice-Edwards,R.D. Illingworth,P.G. Richards,C. Kennard,I. Colquhoun,P. Lewis,Malcolm F. G. Stevens +10 more
TL;DR: Temozolomide was well tolerated with little subjective toxicity and usually predictable myelosuppression and is a promising new drug in the treatment of primary brain tumours.
Journal ArticleDOI
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
Erica Salvati,Carlo Leonetti,Angela Maria Rizzo,Marco Scarsella,Marcella Mottolese,Rossella Galati,Isabella Sperduti,Malcolm F. G. Stevens,Maurizio D'Incalci,Maria A. Blasco,Giovanna Chiorino,Serge Bauwens,Béatrice Horard,Eric Gilson,Antonella Stoppacciaro,Gabriella Zupi,Annamaria Biroccio +16 more
TL;DR: It is shown that RHPS4 triggers a rapid and potent DNA damage response at telomeres in human transformed fibroblasts and melanoma cells, and the key role of telomere-protective factors TRF2 and POT1 in response to this anti-telomere strategy is revealed.
Journal ArticleDOI
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Tracey D. Bradshaw,Samantha Wrigley,Dong-Fang Shi,R. J. Schultz,K. D. Paull,Malcolm F. G. Stevens +5 more
TL;DR: Compared with standard anti-tumour agents evaluated in the National Cancer Institute in vitro cell panel, benzothiazoles revealed unique profiles of growth inhibition, suggesting a mode(s) of action shared with no known clinically active class of chemotherapeutic agents.
Journal ArticleDOI
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
TL;DR: RHPS4 represents a promising G-quadruplex interactive small molecule that is a potent cell-free inhibitor of human telomerase and induces growth inhibitory effects in human tumor cell lines after prolonged (2-week) exposure to nonacute cytotoxic drug concentrations.